Clinical study
The assessment of immunologic and clinical changes occurring during corticosteroid therapy for allergic bronchopulmonary aspergillosis

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Abstract

Twenty-two patients with allergic bronchopulmonary aspergiliosis have been treated and evaluated for a period ranging from two months to nine years. Twelve are available for periodic blood sampling. Data are presented suggesting the following: (1) Patients with allergic bronchopulmonary aspergillosis have high initial levels of total serum immunogiobulin E (IgE). These levels are significantly higher in those patients who had not been previously treated with prednisone for the control of asthma. (2) Treatment with alternate day prednisone (0.5 mg/kg given on alternate days) causes clinical and roentgenologic improvement as well as marked decreases in total serum IgE but does not necessarily prevent recurrence of the disease. (3) Total and specific IgE against Aspergillus antigen may increase prior to and during exacerbations of disease. (4) Specific IgG and IgE against Aspergillus antigen are increased in most patients with allergic bronchopulmonary aspergillosis and reflect disease activity as evidenced by x-ray and clinical exacerbations in some cases. (5) Lymphocyte transformation using Aspergillus antigen, as measured by the whole blood technic, is present in patients with allergic bronchopulmonary aspergillosis, but serial changes in lymphocyte transformation do not correlate with disease activity. (6) Precipitin reactions are present in patients with allergic bronchopulmonary aspergillosis, but presence or absence does not reflect disease activity in most cases.

References (24)

  • KFW Hinson et al.

    Broncho-pulmonary aspergillosis. A review and a report of eight new cases

    Thorax

    (1952)
  • RA Zimmerman et al.

    Pulmonary Aspergillosis

    Am J Roent

    (1970)
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    This study was supported by U.S. Public Health Service, Grant AI 11403, SCOR Grant HL 15389 and the Ernest S. Bazley Grant.

    1

    From the Section of Allergy-Immunology, Department of Medicine, Northwestern University McGaw Medical Center, Chicago, Illinois.

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