Clinical studyArterial blood gases and pH during sleep in chronic obstructive pulmonary disease☆
References (23)
- et al.
Clinical evaluation of prolonged ambulatory oxygen therapy in chronic airway obstruction
Am J Med
(1968) - et al.
Alveolar gas tensions, pulmonary ventilation and blood pH during physiologic sleep in normal subjects
J Clin Invest
(1958) - et al.
Alterations in respiratory function during natural sleep
J Lab Clin Med
(1959) - et al.
Studies on the physiology of awareness: anoxia and the level of sleep
Br Med J
(1952) - et al.
Oxymeter studies on patients with chronic obstructive emphysema, awake and during sleep
N Engl J Med
(1962) - et al.
Respiratory function during sleep in patients with chronic obstructive lung disease
J Clin Invest
(1966) - et al.
Changes in arterial blood gases during sleep in patients with cardiopulmonary disease (abstract)
Am Rev Respir Dis
(1972) Some interrelations between sleep and disease
Arch Intern Med
(1958)- et al.
Acid-base response to acute carbon dioxide changes in chronic obstructive pulmonary disease
Am Rev Respir Dis
(1973)
Pulmonary insufficiency
Medicine
Cited by (115)
Sleep Deficiency, Sleep Apnea, and Chronic Lung Disease
2022, Clinics in Chest MedicineSerotonin neurons and central respiratory chemoreception: Where are we now?
2014, Progress in Brain ResearchStandard nonspecific therapies in the management of pulmonary arterial hypertension
2013, Clinics in Chest MedicineCitation Excerpt :In addition, no improvement in 6-minute walk distances, hematocrit levels, or quality of life were seen in the oxygen-treated group.15 Patients with obstructive sleep apnea (OSA) generally have mild to moderate PH.16–18 Moderate to severe PH should not be attributed to sleep disordered breathing in these patients and other causes such as pulmonary venous hypertension related to diastolic dysfunction from obesity cardiomyopathy or concurrent COPD should be looked for. In OSA-related PH, continuous positive airway pressure (CPAP) combined with oxygen therapy (when needed) result in a more pronounced decrease in mean PAP and PVR than that seen in patients treated with oxygen alone.
Sleep and pulmonary diseases
2011, Handbook of Clinical NeurologyCitation Excerpt :These findings were confirmed by nocturnal arterial blood gas measurements (Pierce et al., 1966). Using electroencephalographic measurements, further studies have demonstrated that nocturnal hypercapnia and hypoxemia episodes were closely related to REM sleep periods (Koo et al., 1975; Leitch et al., 1976; Coccagna and Lugaresi, 1978). The longer the REM duration, the more profound is the hypoxemia (Connaughton et al., 1988).
Oxygen therapy for patients with COPD: Current evidence and the long-term oxygen treatment trial
2010, ChestCitation Excerpt :Because the mechanisms of desaturation during exercise and during sleep differ, patients who desaturate with activity may not desaturate at night. Nocturnal oxygen desaturation (NOD) has been reported in patients with COPD with an awake Pao2 > 60 mm Hg.39–45 The most significant episodes of NOD occur during rapid eye movement sleep, with a reported prevalence of 27%.46
The severity of sleep hypoventilation in stable chronic obstructive pulmonary disease
2021, Sleep and Breathing
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This study was supported in part by National Heart and Lung Pulmonary Special Center of Research Grant HL-15063 and in part by Academic Training Grant, National Institute of General Medicine No. GM-01753.
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From the Medical and Neurology Services, Boston Veterans Administration Hospital; and the Departments of Medicine and Neurology, Boston University School of Medicine, Boston, Massachusetts.
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Present address: 142 West Park, Bloomingdale, Illinois 60108.