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Leukotrienes in pulmonary arterial hypertension

  • IMMUNOLOGY AT STANFORD UNIVERSITY
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Abstract

Leukotrienes (LTs) are lipid mediators derived from the 5-lipoxygenase (5-LO) pathway of arachidonic acid metabolism and are markers and mediators of pulmonary inflammation. Research over the past two decades has established that LTs modulate inflammation in pulmonary arterial hypertension (PAH). The purpose of this review was to summarize the current knowledge of LTs in the pathophysiology of PAH and to highlight a recent study that advances our understanding of how leukotriene B4 (LTB4) specifically contributes to pulmonary vascular remodeling. The results of these studies suggest that pharmacological inhibition of LT pathways, especially LTB4, has high potential for the treatment of PAH.

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Conflict of interest

WT and MRN and Stanford University (OTL #S11-438) have a patent pending concerning the use of LTB4 antagonists for the treatment of PAH.

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  1. VA Palo Alto Health Care System, Stanford University, Med111P, 3801 Miranda Ave., Palo Alto, CA, 94304, USA

    Wen Tian, Xinguo Jiang, Yon K. Sung, Jin Qian & Mark R. Nicolls

  2. Stanford University School of Medicine, Stanford, CA, 94305, USA

    Ke Yuan

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  1. Wen Tian
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  2. Xinguo Jiang
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Tian, W., Jiang, X., Sung, Y.K. et al. Leukotrienes in pulmonary arterial hypertension. Immunol Res 58, 387–393 (2014). https://doi.org/10.1007/s12026-014-8492-5

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