Abstract
Acinetobacter infections have been attracting increasing attention during recent years because they have become common in hospitalized patients, especially in the intensive care unit (ICU) setting. However, the available literature suggests that the pathogen has another fearful potential; it can cause community-acquired infections. We searched PubMed and the reference lists of the initially identified articles and identified six case series regarding a total of 80 patients with community-acquired Acinetobacter baumannii infections; from these, 51 had pneumonia and 29 had bacteremia. Of these 80 patients, 45 (56%) died of the infection. In addition, we identified 26 case reports regarding 43 patients with community-acquired Acinetobacter infections; from these, 38 had pneumonia, two had meningitis, one had soft-tissue infection, one had ocular infection, and one had native valve endocarditis. Comorbidity was commonly present in patients reported in the case series as well as the case reports, mainly, chronic obstructive pulmonary disease, renal disease, and diabetes mellitus; heavy smoking and excess alcohol consumption were also common. Most of the studies originated from China, Taiwan, and tropical Australia. We also identified 12 retrospective or prospective studies (seven from the Far East, two from Oceania, one from N. Guinea, one from Palestine, and one from USA/Canada) that reported the frequency of community-acquired Acinetobacter infections; the range of isolation of Acinetobacter from patients with community-acquired pneumonia in these studies was 1.3%–25.9%. In conclusion, most community-acquired Acinetobacter infections have been reported from countries with tropical or subtropical climate, and mainly affect patients with some form of comorbidity or are associated with heavy smoking and excess alcohol consumption.
Similar content being viewed by others
References
Falagas ME, Karveli EA (2007) The changing global epidemiology of Acinetobacter baumannii infections: a development with major public health implications. Clin Microbiol Infect 13(2):117–119
Fournier PE, Richet H (2006) The epidemiology and control of Acinetobacter baumannii in health care facilities. Clin Infect Dis 42(5):692–699
Falagas ME, Kopterides P, Siempos II (2006) Attributable mortality of Acinetobacter baumannii infection among critically ill patients. Clin Infect Dis 43(3):389
Falagas ME, Bliziotis IA, Siempos II (2006) Attributable mortality of Acinetobacter baumannii infections in critically ill patients: a systematic review of matched cohort and case–control studies. Crit Care 10(2):R48
Anstey NM, Currie BJ, Hassell M, Palmer D, Dwyer B, Seifert H (2002) Community-acquired bacteremic Acinetobacter pneumonia in tropical Australia is caused by diverse strains of Acinetobacter baumannii, with carriage in the throat in at-risk groups. J Clin Microbiol 40(2):685–686
Prashanth K, Ranga MP, Rao VA, Kanungo R (2000) Corneal perforation due to Acinetobacter junii: a case report. Diagn Microbiol Infect Dis 37(3):215–217
Reindersma P, Nohlmans L, Korten JJ (1993) Acinetobacter, an infrequent cause of community acquired bacterial meningitis. Clin Neurol Neurosurg 95(1):71–73
Bilgic H, Akin ES, Tasan Y, Ekiz K, Seber O (1995) A case of Acinetobacter calcoaceticus pneumonia. Thorax 50(3):315–318
Barnes DJ, Naraqi S, Igo JD (1988) Community-acquired acinetobacter pneumonia in adults in Papua New Guinea. Rev Infect Dis 10(3):636–639
Fernández Guerrero ML, Diaz Fernández JL, de Miguel Prieto J, Gómez Garcés JL (1980) Community-acquired Acinetobacter pneumonia. Chest 78(4):670
Bick JA, Semel JD (1993) Fulminant community-acquired Acinetobacter pneumonia in a healthy woman. Clin Infect Dis 17(4):820–821
Rudin ML, Michael JR, Huxley EJ (1979) Community-acquired acinetobacter pneumonia. Am J Med 67(1):39–43
Sharma A, Shariff M, Thukral SS, Shah A (2005) Chronic community-acquired Acinetobacter pneumonia that responded slowly to rifampicin in the anti-tuberculous regime. J Infect 51(3):149–152
Carter JD, Cutolo EP, Behnke RH, Adelman HM (1999) Pulmonary infiltrates in an elderly man. Hosp Pract 34(8):21–22
Suchyta MR, Peters JI, Black RD (1987) Chronic Acinetobacter calcoaceticus var anitratus pneumonia. Am J Med Sci 294(2):117–119
Thornley MJ (1967) A taxonomic study of Acinetobacter and related genera. J Gen Microbiol 49(2):211–257
Henriksen SD (1973) Moraxella, Acinetobacter, and the Mimeae. Bacteriol Rev 37(4):522–561
Leung WS, Chu CM, Tsang KY, Lo FH, Lo KF, Ho PL (2006) Fulminant community-acquired Acinetobacter baumannii pneumonia as a distinct clinical syndrome. Chest 129(1):102–109
Chen HP, Chen TL, Lai CH, Fung CP, Wong WW, Yu KW, Liu CY (2005) Predictors of mortality in Acinetobacter baumannii bacteremia. J Microbiol Immunol Infect 38(2):127–136
Wang JT, McDonald LC, Chang SC, Ho M (2002) Community-acquired Acinetobacter baumannii bacteremia in adult patients in Taiwan. J Clin Microbiol 40(4):1526–1529
Chen MZ, Hsueh PR, Lee LN, Yu CJ, Yang PC, Luh KT (2001) Severe community-acquired pneumonia due to Acinetobacter baumannii. Chest 120(4):1072–1077
Anstey NM, Currie BJ, Withnall KM (1992) Community-acquired Acinetobacter pneumonia in the Northern Territory of Australia. Clin Infect Dis 14(1):83–91
Chiang WC, Su CP, Hsu CY, Chen SY, Chen YC, Chang SC, Hsueh PR (2003) Community-acquired bacteremic cellulitis caused by Acinetobacter baumannii. J Formos Med Assoc 102(9):650–652
Drault JN, Herbland A, Kaidomar S, Mehdaoui H, Olive C, Jouanelle J (2001) Community-acquired Acinetobacter baumannii pneumonia (in French). Ann Fr Anesth Reanim 20(9):795–798
Chang WN, Lu CH, Huang CR, Chuang YC (2000) Community-acquired Acinetobacter meningitis in adults. Infection 28(6):395–397
Yang CH, Chen KJ, Wang CK (1997) Community-acquired Acinetobacter pneumonia: a case report. J Infect 35(3):316–318
Achar KN, Johny M, Achar MN, Menon NK (1993) Community-acquired bacteraemic Acinetobacter pneumonia with survival. Postgrad Med J 69(818):934–937
Bernasconi E, Wüst J, Speich R, Flury G, Krause M (1993) Community-acquired Acinetobacter pneumonia (in German). Schweiz Med Wochenschr 123(33):1566–1571
Gradon JD, Chapnick EK, Lutwick LI (1992) Infective endocarditis of a native valve due to Acinetobacter: case report and review. Clin Infect Dis 14(5):1145–1148
Gottlieb T, Barnes DJ (1989) Community-acquired Acinetobacter pneumonia. Aust N Z J Med 19(3):259–260
Krisanapan S, Naphathorn P, Kaewprom P (1989) Community acquired Acinetobacter pneumonia: report of two cases. Southeast Asian J Trop Med Public Health 20(3):497–498
Westh H, Terp J (1988) Community-acquired bacteremic Acinetobacter calcoaceticus var. anitratus pneumonia. Infection 16(5):303–304
Henderson ST, Torrez AJ Jr, Clement KD (1987) Community-acquired nonbacteremic acinetobacter pneumonia. J Fam Pract 25(6):609–610
Vathesatogkit P, Charoenphan P, Saenghirunvattana S, Kiatboonsri S, Sathapatayavongs B (1987) Community-acquired Acinetobacter pneumonia in Thailand. Report of 5 cases. J Med Assoc Thai 70(2):96–101
Cordes LG, Brink EW, Checko PJ, Lentnek A, Lyons RW, Hayes PS, Wu TC, Tharr DG, Fraser DW (1981) A cluster of Acinetobacter Pneumonia in foundry workers. Ann Intern Med 95(6):688–693
Goodhart GL, Abrutyn E, Watson R, Root RK, Egert J (1977) Community-acquired Acinetobacter calcoaceticus var anitratus pneumonia. JAMA 238(14):1516–1518
Wallace RJ Jr, Awe RJ, Martin RR (1976) Bacteremic Acinetobacter Herellea pneumonia with survival: case report. Am Rev Respir Dis 113(5):695–699
Wands JR, Mann RB, Jackson D, Butler T (1973) Fatal community-acquired Herellea pneumonia in chronic renal disease. Case report. Am Rev Respir Dis 108(4):964–967
Hu H-C, Huang C-C, Tsai Y-H, Lee C-H, Hsieh M-J (2005) Outcome analysis of patients requiring mechanical ventilation with severe community-acquired pneumonia and identified bacterial pathogens. Chang Gung Med J 28(4):229–235
Lau SM, Peng MY, Chang FY (2004) Resistance rates to commonly used antimicrobials among pathogens of both bacteremic and non-bacteremic community-acquired urinary tract infection. J Microbiol Immunol Infect 37(3):185–191
Loh L-C, Khoo S-K, Quah S-Y, Visvalingam V, Radhakrishnan A, Vijayasingham P, Thayaparan T (2004) Adult community-acquired pneumonia in Malaysia: prediction of mortality from severity assessment on admission. Respirology 9(3):379–386
Wu CL, Lee YL, Chang KM, Chang GC, King SL, Chiang CD, Niederman MS (2003) Bronchoalveolar interleukin-1 beta: a marker of bacterial burden in mechanically ventilated patients with community-acquired pneumonia. Crit Care Med 31(3):812–817
Astal Z, El-Manama A, Sharif FA (2002) Antibiotic resistance of bacteria associated with community-acquired urinary tract infections in the southern area of the Gaza Strip. J Chemother 14(3):259–264
Hooi LN, Looi I, Ng AJ (2001) A study on community acquired pneumonia in adults requiring hospital admission in Penang. Med J Malaysia 56(3):275–284
Lu CH, Huang CR, Chang WN, Chang CJ, Cheng BC, Lee PY, Lin MW, Chang HW (2002) Community-acquired bacterial meningitis in adults: the epidemiology, timing of appropriate antimicrobial therapy, and prognostic factors. Clin Neurol Neurosurg 104(4):352–358
Marik PE (2000) The clinical features of severe community-acquired pneumonia presenting as septic shock. Norasept II Study Investigators. J Crit Care 15(3):85–90
Ismail NH, Lieu PK, Lien CT, Ling ML (1997) Bacteraemia in the elderly. Ann Acad Med Singapore 26(5):593–598
Patel MS, Phillips CB, Cabaron Y (1991) Frequent hospital admissions for bacterial infections among aboriginal people with diabetes in central Australia. Med J Aust 155(4):218–222
Karalus NC, Cursons RT, Leng RA, Mahood CB, Rothwell RP, Hancock B, Cepulis S, Wawatai M, Coleman L (1991) Community acquired pneumonia: aetiology and prognostic index evaluation. Thorax 46(6):413–418
Acknowledgment
We thank Professor Li-Cher Loh MD, IMU Lung Research, International Medical University, Kuala Lumpur, Malaysia, for providing us with a relevant article for the review.
Author information
Authors and Affiliations
Corresponding author
Additional information
Authors’ contributions
MEF had the idea for the article and supervised the various stages of its progress. EAK, IK, and TK performed the literature search, study selection, and data extraction. MEF and EAK wrote the first version of the manuscript. All authors approved its final version.
Rights and permissions
About this article
Cite this article
Falagas, M.E., Karveli, E.A., Kelesidis, I. et al. Community-acquired Acinetobacter infections. Eur J Clin Microbiol Infect Dis 26, 857–868 (2007). https://doi.org/10.1007/s10096-007-0365-6
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10096-007-0365-6