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Pulmonary epithelioid hemangioendothelioma: Report of three cases

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Abstract

Pulmonary epithelioid hemangioendothelioma (PEH) is a rare vascular tumor of low-grade malignancy, the prognosis of which remains unpredictable. Surgical and/or chemotherapeutic options have to be evaluated depending on intrathoracic tumor spread and systemic metastases. Three cases of PEH with both clinical and pathological findings are herein summarized and the relevant current literature discussed.

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References

  1. Dail DH, Liebow AA, Gmelich JT, Friedman PJ, Miyai K, Myer W, et al. Intravascular, bronchiolar, and alveolar tumor of the lung (IVBAT). An analysis of twenty cases of a peculiar sclerosing endothelial tumor. Cancer 1983;51(3):452–464.

    Article  PubMed  CAS  Google Scholar 

  2. Weiss SW, Ishak KG, Dail DH, Sweet DE, Enzinger FM. Epithelioid hemangioendothelioma and related lesions. Semin Diagn Pathol 1986;3(4):259–287.

    PubMed  CAS  Google Scholar 

  3. Weldon-Linne CM, Victor TA, Christ ML. Immunohistochemical identification of factor VIII-related antigen in the intravascular bronchioloalveolar tumor of the lung. Arch Pathol Lab Med 1981;105(11):628–629.

    PubMed  CAS  Google Scholar 

  4. Fukayama M, Nihei Z, Takizawa T, Kawaguchi K, Harada H, Koike M. Malignant epithelioid hemangioendothelioma of the liver, spreading through the hepatic veins. Virchows Arch A Pathol Anat Histopathol 1984;404(3):275–287.

    Article  PubMed  CAS  Google Scholar 

  5. Amin RM, Hiroshima K, Kokubo T, Nishikawa M, Narita M, Kuroki M, et al. Risk factors and independent predictors of survival in patients with pulmonary epithelioid haemangioendothelioma. Review of the literature and a case report. Respirology 2006;11(6):818–825.

    Article  PubMed  Google Scholar 

  6. Mukundan G, Urban BA, Askin FB, Fishman EK. Pulmonary epithelioid hemangioendothelioma: atypical radiologic findings of a rare tumor with pathologic correlation. J Comput Assist Tomogr 2000;24(5):719–720.

    Article  PubMed  CAS  Google Scholar 

  7. Kitaichi M, Nagai S, Nishimura K, Itoh H, Asamoto H, Izumi T, et al. Pulmonary epithelioid haemangioendothelioma in 21 patients, including three with partial spontaneous regression. Eur Respir J 1998;12(1):89–96.

    Article  PubMed  CAS  Google Scholar 

  8. Einsfelder B, Kuhnen C. Epithelioid hemangioendothelioma of the lung (IVBAT) — clinicopathological and immunohistochemical analysis of 11 cases (in German). Pathologe 2006;27(2): 106–115.

    Article  PubMed  CAS  Google Scholar 

  9. Bagan P, Hassan M, Le Pimpec Barthes F, Peyrard S, Souilamas R, Danel C, et al. Prognostic factors and surgical indications of pulmonary epithelioid hemangioendothelioma: a review of the literature. Ann Thorac Surg 2006;82(6):2010–2013.

    Article  PubMed  Google Scholar 

  10. Carter EJ, Bradburne RM, Jhung JW, Ettensohn DB. Alveolar hemorrhage with epithelioid hemangioendothelioma. A previously unreported manifestation of a rare tumor. Am Rev Respir Dis 1990;142(3):700–701.

    PubMed  CAS  Google Scholar 

  11. Yi ES, Auger WR, Friedman PJ, Morris TA, Shin SS. Intravascular bronchioloalveolar tumor of the lung presenting as pulmonary thromboembolic disease and pulmonary hypertension. Arch Pathol Lab Med 1995;119(3):255–260.

    PubMed  CAS  Google Scholar 

  12. Rock MJ, Kaufman RA, Lobe TE, Hensley SD, Moss ML. Epithelioid hemangioendothelioma of the lung (intravascular bronchioloalveolar tumor) in a young girl. Pediatr Pulmonol 1991; 11(2):181–186.

    Article  PubMed  CAS  Google Scholar 

  13. Bharadwaj R, Hejmadi R, Mistry R, Desai S. Pericardial effusion and raised CA-125 level — unusual manifestations of primary pulmonary epithelioid hemangioendothelioma. Indian J Cancer 1999;36(2–4):194–197.

    PubMed  CAS  Google Scholar 

  14. Sakamoto N, Adachi S, Monzawa S, Hamanaka A, Takada Y, Hunada Y, et al. High resolution CT findings of pulmonary epithelioid hemangioendothelioma: unusual manifestations in 2 cases. J Thorac Imaging 2005;20(3):236–238.

    Article  PubMed  Google Scholar 

  15. Travis WD, Brambilla E, Mueller-Hermelink HK, Harris CC. Pathology and genetics of tumours of the lung, pleura, thymus and heart. WHO classification of tumours. Lyon: IARC Press; 2004.

    Google Scholar 

  16. Mendlick MR, Nelson M, Pickering D, Johansson SL, Seemayer TA, Neff JR, et al. Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma. Am J Surg Pathol 2001;25(5):684–687.

    Article  PubMed  CAS  Google Scholar 

  17. Boudousquie AC, Lawce HJ, Sherman R, Olson S, Magenis RE, Corless CL. Complex translocation [7;22] identified in an epithelioid hemangioendothelioma. Cancer Genet Cytogenet 1996; 92(2):116–121.

    Article  PubMed  CAS  Google Scholar 

  18. Eggleston JC. The intravascular bronchioloalveolar tumor and the sclerosing hemangioma of the lung: misnomers of pulmonary neoplasia. Semin Diagn Pathol 1985;2(4):270–280.

    PubMed  CAS  Google Scholar 

  19. Sicilian L, Warson F, Carrington CB, Hayes J, Gaensler EA. Intravascular bronchioloalveolar tumor (IV-BAT). Respiration 1983;44(5):387–394.

    Article  PubMed  CAS  Google Scholar 

  20. Hanada N, Namai S, Kobayashi C, Igawa S, Ozawa T, Kobayashi H, et al. Case report of pulmonary epithelioid hemangioendothelioma (in Japanese). Nihon Kokyuki Gakkai Zasshi 2003;41(2): 144–149.

    PubMed  Google Scholar 

  21. Nakatani Y, Aoki I, Misugi K. Immunohistochemical and ultrastructural study of early lesions of intravascular bronchioloalveolar tumor with liver involvement. Acta Pathol Jpn 1985;35(6): 1453–1465.

    PubMed  CAS  Google Scholar 

  22. Miettinen M, Collan Y, Halttunen P, Maamies T, Vilkko P. Intravascular bronchioloalveolar tumor. Cancer 1987;60(10):2471–2475.

    Article  PubMed  CAS  Google Scholar 

  23. van Kasteren ME, van der Wurff AA, Palmen FM, Dolman A, Misere JF. Epithelioid haemangioendothelioma of the lung: clinical and pathological pitfalls. Eur Respir J 1995;8(9): 1616–1619.

    PubMed  Google Scholar 

  24. Schattenberg T, Pfannschmidt J, Herpel E, Schnabel PA, Mechtersheimer G, Dienemann H. Bilateral surgical resection in pulmonary epitheloid hemangioendothelioma. Thorac Cardiovasc Surg 2007;55(3):199–200.

    Article  PubMed  CAS  Google Scholar 

  25. Ross GJ, Violi L, Friedman AC, Edmonds PR, Unger E. Intravascular bronchioloalveolar tumor: CT and pathologic correlation. J Comput Assist Tomogr 1989;13(2):240–243.

    Article  PubMed  CAS  Google Scholar 

  26. Yanagawa H, Hashimoto Y, Bando H, Takishita Y, Nagano T. Intravascular bronchioloalveolar tumor with skin metastases. Chest 1994;105(6):1882–1884.

    Article  PubMed  CAS  Google Scholar 

  27. Diaz R, Segura A, Calderero V, Cervera I, Aparicio J, Jorda MV, et al. Central nervous system metastases of a pulmonary epitheloid haemangioendothelioma. Eur Respir J 2004;23(3): 483–486.

    Article  PubMed  CAS  Google Scholar 

  28. Cronin P, Arenberg D. Pulmonary epithelioid hemangioendothelioma: an unusual case and a review of the literature. Chest 2004; 125(2):789–793.

    Article  PubMed  Google Scholar 

  29. Chen TM, Donington J, Mak G, Berry GJ, Ruoss SJ, Rosen GD, et al. Recurrence of pulmonary intravascular bronchoalveolar tumor with mediastinal metastasis 20 years later. Respir Med 2006;100(2):367–370.

    Article  PubMed  Google Scholar 

  30. Roudier-Pujol C, Enjolras O, Lacronique J, Guillemette J, Herbreteau D, Leibowitch M, et al. Multifocal epithelioid hemangioendothelioma with partial remission after interferon alpha-2a treatment (in French). Ann Dermatol Venereol 1994;121(12): 898–904.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Thoracic Surgery, Thoraxklinik Heidelberg, University of Heidelberg, Amalienstrasse 5, D-69126, Heidelberg, Germany

    Torsten Schattenberg, Richard Kam, Michael Klopp, Hendrik Dienemann & Joachim Pfannschmidt

  2. Department of Pathology, University of Heidelberg, Amalienstrasse 5, D-69126, Heidelberg, Germany

    Esther Herpel, Philipp Albert Schnabel & Gunhild Mechtersheimer

Authors
  1. Torsten Schattenberg
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  2. Richard Kam
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  3. Michael Klopp
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  4. Esther Herpel
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  5. Philipp Albert Schnabel
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  6. Gunhild Mechtersheimer
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  7. Hendrik Dienemann
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  8. Joachim Pfannschmidt
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Schattenberg, T., Kam, R., Klopp, M. et al. Pulmonary epithelioid hemangioendothelioma: Report of three cases. Surg Today 38, 844–849 (2008). https://doi.org/10.1007/s00595-007-3712-4

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  • DOI: https://doi.org/10.1007/s00595-007-3712-4

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