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The sodium phosphate cotransporter family SLC34

  • The ABC of Solute Carriers
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Abstract

This review summarizes the characteristics of the solute carrier family SLC34 that is represented by the type ll Na/Pi-cotransporters NaPi-lla (SLC34A1), NaPi-llb (SLC34A2) and NaPi-llc (SLC34A3). Other Na/Pi-cotransporters are described within the SLC17 and SLC20 families. Type ll Na/Pi-cotransporters are expressed in several tissues and play a major role in the homeostasis of inorganic phosphate. In kidney and small intestine, type ll Na/Pi-cotransporters are located at the apical sites of epithelial cells and represent the rate limiting steps for transepithelial movement of phosphate. Physiological and pathophysiological regulation of renal and small intestinal epithelial transport of phosphate occurs through alterations in the abundance of type ll Na/Pi-cotransporters.

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Acknowledgements

We thank the Swiss Science National Foundations and other Swiss financial institutions for their financial support.

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Authors and Affiliations

  1. Institute of Physiology, University of Zürich-Irchel, Winterthurerstrasse 190, 8057, Zürich, Switzerland

    Heini Murer, Ian Forster & Jürg Biber

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  1. Heini Murer
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  2. Ian Forster
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  3. Jürg Biber
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Correspondence to Heini Murer.

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Murer, H., Forster, I. & Biber, J. The sodium phosphate cotransporter family SLC34. Pflugers Arch - Eur J Physiol 447, 763–767 (2004). https://doi.org/10.1007/s00424-003-1072-5

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  • DOI: https://doi.org/10.1007/s00424-003-1072-5

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