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Significant improvement of right ventricular function by imatinib mesylate in scleroderma-associated pulmonary arterial hypertension

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References

  1. Atallah E, Durand JB, Kantarijan H, Cortes J (2007) Congestive heart failure is a rare event in patients receiving imatinib therapy. Blood 110:1233–1237

    Article  PubMed  CAS  Google Scholar 

  2. Baroni SS, Santillo M, Bevilacqua F, Luchetti M, Spadoni T, Mancini M, Fraticelli P, Sambo P, Funaro A, Kazlauskas A, Avvedimento EV, Gabrielli A (2006) Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. N Engl J Med 354:2667–2676

    Article  PubMed  CAS  Google Scholar 

  3. Ghofrani HA, Seeger W, Grimminger F (2005) Imatinib for the treatment of pulmonary arterial hypertension. N Engl J Med 353:1412–1413

    Article  PubMed  CAS  Google Scholar 

  4. Kerkelä R, Grazette L, Yacobi R et al (2006) Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med 12:908–916

    Article  PubMed  Google Scholar 

  5. Olschewski H, Höper MM, Borst MM et al (2007) Diagnostik und Therapie der chronischen pulmonalen Hypertonie. Leitlinien der Deutschen Gesellschaft für Pneumologie, der Deutschen Gesellschaft für Kardiologie und der Deutschen Gesellschaft für Pädiatrische Kardiologie. Clin Res Cardiol 96:301–330

    Article  PubMed  Google Scholar 

  6. Overbeek JM, Lankhaar JW, Westerhof N et al (2008) Right ventricular contractility in systemic sclerosis-associated and idiopathic pulmonary arterial hypertension. Eur Respir J 31:1160–1166

    Article  PubMed  CAS  Google Scholar 

  7. Patterson KC, Weissmann A, Ahmadi T, Farber HW (2006) Imatinib mesylate in the treatment of refractory idiopathic pulmonary arterial hypertension. Ann Intern Med 145:152–153

    PubMed  Google Scholar 

  8. Rosenkranz S (2007) Pulmonary hypertension: current diagnosis and treatment. Clin Res Cardiol 96:527–541

    Article  PubMed  CAS  Google Scholar 

  9. Schermuly RT, Dony E, Ghofrani HA, Grimminger F et al (2005) Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest 115:2811–2821

    Article  PubMed  CAS  Google Scholar 

  10. Souza R, Sitbon O, Parent G, Simonneau G, Humbert M (2006) Long term imatinib treatment in pulmonary arterial hypertension. Chest 61:736

    CAS  Google Scholar 

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All authors report that no significant conflicts of interest exist.

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Authors and Affiliations

  1. Klinik III für Innere Medizin, Universität zu Köln, Kerpener Str. 62, 50937, Köln, Germany

    Henrik ten Freyhaus, Daniel Dumitrescu, Erland Erdmann & Stephan Rosenkranz MD

  2. Klinik für Radiologie, Universität zu Köln, Köln, Germany

    Henning Bovenschulte

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  1. Henrik ten Freyhaus
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  2. Daniel Dumitrescu
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  3. Henning Bovenschulte
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  4. Erland Erdmann
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  5. Stephan Rosenkranz MD
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Correspondence to Stephan Rosenkranz MD.

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ten Freyhaus, H., Dumitrescu, D., Bovenschulte, H. et al. Significant improvement of right ventricular function by imatinib mesylate in scleroderma-associated pulmonary arterial hypertension. Clin Res Cardiol 98, 265–267 (2009). https://doi.org/10.1007/s00392-009-0752-3

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  • DOI: https://doi.org/10.1007/s00392-009-0752-3

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