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Pulmonary non-Hodgkin’s lymphoma developed during long-term methotrexate therapy for rheumatoid arthritis

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Abstract

Methotrexate is effective in treating rheumatoid arthritis (RA). Some reports have discussed the possible association between methotrexate and lymphoma. Here, we report a case of pulmonary non-Hodgkin’s lymphoma (NHL) developed after 11 years’ methotrexate therapy for RA. Biopsy of the pulmonary mass demonstrated a diffuse large B-cell lymphoma. After withdrawal of methotrexate without any other intervention for 4 weeks, a significant reduction in the size of the lymphoma was observed. The causative relationship between methotrexate and pulmonary lymphoma is suggested by the persistent remission after stopping methotrexate therapy.

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Correspondence to Huiying Wang.

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Wang, H., Wu, D., Xiang, H. et al. Pulmonary non-Hodgkin’s lymphoma developed during long-term methotrexate therapy for rheumatoid arthritis. Rheumatol Int 32, 3639–3642 (2012). https://doi.org/10.1007/s00296-010-1496-0

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  • DOI: https://doi.org/10.1007/s00296-010-1496-0

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