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Risk factors for capillary leakage syndrome after bone marrow transplantation

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Abstract

 Age, hematopoietic growth factors, cyclosporin A, mode of bone marrow transplantation (BMT) (autologous, allogeneic-related, unrelated), and underlying disease were assessed as potential risk factors for capillary leakage syndrome (CLS) in 96 patients after BMT. CLS was defined as unexplained weight gain of >3% within 24 h and nonresponsiveness to furosemide. CLS occurred in 9/21 patients after unrelated compared with 2/33 after allogeneic-related BMT (p=0.0017) for hematopoietic disorders (n=54) and in 6/7 patients after allogeneic-related compared with 3/35 after autologous BMT (p=0.0001) for solid tumors (n=42). Hematopoietic growth factors and cyclosporin A were no signficant risk factors on their own. We conclude that unrelated BMTs or high-intensity conditioning regimens used in combination with allogeneic-related BMT are the main risk factors for CLS.

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Received: 6 January 1997 / Accepted: 10 March 1997

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Nürnberger, W., Willers, R., Burdach, S. et al. Risk factors for capillary leakage syndrome after bone marrow transplantation. Ann Hematol 74, 221–224 (1997). https://doi.org/10.1007/s002770050288

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  • DOI: https://doi.org/10.1007/s002770050288

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