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Biological implications of preformed mast cell mediators

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Abstract

Mast cells store an impressive array of preformed compounds (mediators) in their secretory granules. When mast cells degranulate, these are released and have a profound impact on any condition in which mast cell degranulation occurs. The preformed mast cell mediators include well-known substances such as histamine, proteoglycans, proteases, and preformed cytokines, as well as several recently identified compounds. Mast cells have recently been implicated in a large number of novel pathological settings in addition to their well-established contribution to allergic reactions, and there is consequently a large current interest in the molecular mechanisms by which mast cells act in the context of a given condition. In many cases, preformed mast cell mediators have been shown to account for functions ascribed to mast cells, and these compounds are hence emerging as major players in numerous pathologies. In this review we summarize the current knowledge of preformed mast cell mediators.

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Acknowledgments

The authors of this article receive support from The Swedish Research Council, Formas, King Gustaf V:s 80-year Anniversary Fund, Torsten and Ragnar Söderberg Foundation and The Swedish Cancer Foundation.

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  1. Department of Anatomy, Physiology and Biochemistry, BMC, Swedish University of Agricultural Sciences, Box 575, 75123, Uppsala, Sweden

    Anders Lundequist & Gunnar Pejler

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  1. Anders Lundequist
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  2. Gunnar Pejler
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Correspondence to Gunnar Pejler.

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Lundequist, A., Pejler, G. Biological implications of preformed mast cell mediators. Cell. Mol. Life Sci. 68, 965–975 (2011). https://doi.org/10.1007/s00018-010-0587-0

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