TABLE 2

Clinical trials for COPD registered at clinicaltrials.gov (accessed 9 September 2022)

Registry codeEnrolment (S/C)Follow-upIntervention (cell source)Delivery routeCurrent statusPhase
NCT03044431207/1486 monthsAutologous PB-SCs and/or BM-MSCsIntravenousCompletedNA
NCT0404781015/–1 dayAllogeneic MSCsIntravenousOngoing (recruiting)I
NCT0264530520/–12 monthsAutologous AD-MSCsIntravenousUnknownI/II
NCT011102524/430 daysAutologous BMMCsIntravenousCompletedNA
NCT0241233220/2012 monthsAutologous BMMCs and/or AD-MSCsIntravenousUnknownI/II
NCT0443310440/–12 monthsAllogeneic UC-MSCsIntravenousOngoing (recruiting)I/II
NCT0221663026/–12 monthsAutologous AD-MSCsIntravenousCompletedI/II
NCT042060079/–15 monthsAllogeneic UC-MSCsIntravenousOngoing (recruiting)I
NCT032281210/06 monthsAutologous MSCsIntravenousWithdrawnNA
NCT0514768820/–48 monthsAllogeneic UC-MSCsIntravenousOngoing (recruiting)I
NCT03040674489/2416 monthsAutologous PB-SCs and/or BM-MSCIntravenousCompletedNA
NCT0401872934/–6 monthsBM-MSCsEndobronchialUnknownII/III
NCT0068372262/6224 monthsAllogeneic MSCs (Prochymal)IntravenousCompletedII
NCT021617449/–12 monthsAutologous AD-MSCsIntravenousTerminated (poor enrolment)I
NCT038992985000/–120 monthsAmniotic tissue-derived and UC-MSCsIntravenous plus nebuliserOngoing (not yet recruiting)I
NCT0191657715/1512 monthsAutologous BMMCs (mobilisation)Plerixafor applied subcutaneouslyCompletedI
NCT020410000/06 monthsAutologous AD-MSCsIntravenousWithdrawnNA
NCT019535233000/–120 monthsAutologous AD-MSCsIntravenous, intra-articular and soft tissue injectionCompletedNA
NCT02348060100/–12 monthsAutologous AD-MSCsNMUnknownNM
NCT015590510/06 monthsAutologous AD-MSCsIntravenousWithdrawn (company dissolved)I/II
NCT0302168118/–24 monthsAutologous bronchial basal cellsBronchoscope transfusionCompletedNA
NCT0491870630/–48–60 monthsAllogeneic BM-MSCsIntravenousOngoing (recruiting)II
NCT018491590/024 monthsAllogeneic BM-MSCsIntravenousWithdrawnI/II
NCT0175805512/–12 monthsAutologous BM-MSCsEndobronchialUnknownI
NCT0130651310/1012 monthsAutologous BM-MSCsIntravenousCompletedI

AD-MSC: adipose tissue-derived mesenchymal stem cell; BM-MSC: bone marrow-derived mesenchymal stem cell; BMMC: bone marrow mononuclear cell; MSC: mesenchymal stem/stromal cell; NCT: National Clinical Trial (clinicaltrials.gov); NA: not applicable; NM: not mentioned; PB-SC: peripheral blood stem cell; S/C: started/completed; UC-MSC: umbilical cord-derived mesenchymal stem cell.