Characteristics of 30 included systematic reviews for adult-onset asthma, ranked by Joanna Briggs Institute (JBI) score

AuthorsRisk factor(s)Main findingsAdult-onset asthma#JBI score
Romero Starke et al. [20]Occupational exposure to cleaning and disinfection agentsNurses exposed to cleaning products to have an increased risk of asthma.Yes11
Yu et al. [21]Formaldehyde exposureA significantly increased risk of asthma in adults with high concentrations of formaldehyde exposure was found.Unclear11
Wang et al. [22]Exposure to greennessThe results are contradictory, with all three included studies showing different associations.Unclear10
Chen et al. [23]Zinc and selenium levelsThe meta-analysis provides evidence that lower circulating Zn and Se levels are associated with an increased risk of asthma.Unclear10
Etminan et al. [24]Acetaminophen useThe results are consistent with an increase in the risk of asthma in adults exposed to acetaminophen.Unclear10
Zhang et al. [25]Organic dust exposureThe meta-analysis found organic dust exposure to be a risk factor for asthma.No9
Shen et al. [26]Early life vitamin D deficiencyNo statistically significant association between early life vitamin D deficiency and asthma development later in life was found.Unclear9
Nurmatov et al. [27]Volatile organic compoundsThe results of the effect on volatile organic compounds on the development of asthma are inconsistent.Unclear9
Sharpe et al. [28]Exposure to indoor fungiExposure to certain species of fungi might increase the risk of developing asthma.Unclear9
Mu et al. [29]Birth weightThe results suggest that low birth weight (<2500 g) is associated with increased risk of asthma both in children in adults, but high birth weight (>4000 g) was not associated with increased risk of asthma.Unclear9
Macan et al. [30]PersulphatesPersulphates were associated with asthma in hairdressers, in particular bleaching products.Yes8
Sio et al. [31]Wide rangeThe study showed housing related factors such as mould, male sex, smoke exposure and BMI-related factors to be associated with asthma.Mixed8
Rodriguez et al. [32]Urban–rural differencesThe findings provide evidence that urban residence and urbanisation are important determinants of asthma.Unclear8
Cong et al. [33]Temperature changesThere was no increased risk for asthma development in adults when temperature dropped.No8
Wiggans et al. [34]Wood dustWork in this sector was associated with a significantly increased risk of respiratory symptoms and asthma.Unclear8
Uphoff et al. [35]Socioeconomic positionLow socioeconomic position was found to be associated with asthma risk.Unclear8
Tan et al. [36]Risk factors associated with age of onsetAdults with late-onset current asthma are more likely to be female (58–75%), smokers (56%).Yes8
Lieberoth et al. [37]Age at menarcheEarly menarche (<12 years) appears to be associated with increased risk of asthma.Unclear8
Kakutani et al. [38]Arachidonic acid intakeThe results suggest that arachidonic acid exposure is not consistently associated with asthma risk.Mixed8
Takkouche et al. [39]Exposure to furry petsIn adults, the evidence regarding either an increased or decreased risk of asthma when exposed to furry pets is inconclusive.Unclear8
Beuther et al. [40]BMIHigher BMI is associated with developing asthma.Yes8
Jaakkola et al. [41]Pre-term deliveryPremature babies seem to have an increased risk of developing asthma later in life, but the results in adults are inconclusive.Unclear8
Mikkelsen et al. [42]Wide rangeA higher BMI and early puberty increase asthma risk. Lifetime smoking, alcohol consumption, late puberty and linoleic acid seem to be protective factors. Vitamin B12, iron and folate intake are not significant.Yes7
Canova et al. [43]Domestic paintsThe variable quality of the exposure assignment makes it difficult to draw firm conclusions on whether there is an association.Unclear7
Baur et al. [44]Workplace irritantsThere is evidence that long-term exposure to workplace irritants could increase asthma development.Unclear7
Flaherman et al. [45]High childhood BMIHigh body weight in childhood seems to increase the risk of asthma later in life. However, in adults, results are not conclusive.Yes7
Doust et al. [46]Pesticide exposureThe results were suggestive of potentially adverse associations between pesticide exposure and an increased likelihood of asthma.Mixed7
Jaakkola et al. [47]Exposure to phthalatesHeated PVC fumes possibly contribute to development of asthma in adults.Unclear6
Folletti et al. [48]Cleaning work/productsIncreased risk of asthma has been shown when exposed to cleaning products.Unclear6
Vincent et al. [49]Cleaning productsThe evidence linking exposure to cleaning agents as a risk factor for causing new onset asthma is limited.No6

#Adult-onset asthma indicates whether the study specifies if the target group had adult-onset asthma or whether it is asthma in adults. BMI: body mass index; PVC: polyvinyl chloride.