Disease | Changes in autophagy receptors and markers | Reference |
ALI | Atg7, Atg5, Atg4B | [41, 49] |
COPD | PINK1, PARK2, p62, LC3-II, Beclin-1, histone deacetylase 6, Bcl-2:XIAP, PARP, CD63, LAMP1 | [56–58, 64–66] |
Asthma | LC3, Atg5, Beclin-1, p62, Zn, ZIP1, ZIP2, PINK1, Parkin | [37, 73–77] |
IPF | PI3K/Akt pathway, PTEN, Beclin-1:mTOR signalling pathway, Atg7, Bcl-2 complex, p62, LC3-II, LC3βII, Atg5–12 | [86–88] |
ALI: acute lung injury; IPF: idiopathic pulmonary fibrosis; LAMP1: lysosomal-associated membrane protein 1; LC3: light chain 3; LC3-II: light chain 3 phosphatidylethanolamine conjugate; mTOR: mammalian target of rapamycin; PARP: poly-(ADP)-ribose polymerase; PINK1: PTEN-inducible putative kinase 1; PTEN: phosphatase and tensin homologue; XIAP: X-linked inhibitor of apoptosis protein; ZIP: zinc transporter.