Ongoing clinical studies investigating inhaled corticosteroid treatment for coronavirus disease 2019 (COVID-19) in adults

Trial no.NameTreatmentSettingPrimary outcomen (planned)Start dateEstimated or actual primary completion dateLocation
JPRN-jRCTs031190269 [83]RACCOCiclesonide 400 µg three times daily for 7 daysHospitalIncidence of pneumonia on day 8 following treatment90April 2020October 2020Japan
NCT04381364 [84]HALT COVID-19Ciclesonide 320 µg twice daily for 14 days versus standard careHospitalDuration (days) of received supplemental oxygen therapy within 30 days after study inclusion446May 2020August 2021Sweden
EudraCT 2020-002208-37 [80]CIMMCovCiclesonide 320 µg twice daily for 28 days versus placeboPrimary careReduction in healthcare resource utilisation (renewed contact with GP, emergency department and/or admission to hospital) due to COVID-19-related symptoms138June 2020#OngoingDenmark
CTRI/2020/10/028581 [78]Budesonide Rotacaps 200 µg twice daily for 10–14 days in addition to standard care versus standard care alonePrimary careHospitalisation1000October 2020December 2020India
CTRI/2021/05/033817 [79]Budesonide 400 µg (two puffs twice daily) for up to 28 days versus standard care alonePrimary careHospitalisation or emergency department attendance related to COVID-19820May 2021+UnknownIndia
NCT04937543 [81]TRIVIDBeclomethasone 250 µg or beclomethasone/formoterol/glycopyrronium 100/6/12.5 µg (two doses twice daily) for 28 days in addition to standard care versus standard care alonePrimary careUse of healthcare resources 28 days after treatment260June 2021October 2021Brazil
NCT05054322 [82]FLOTFluticasone propionate 125 µg with spacer (four puffs twice daily) for 14 days in addition to standard carePrimary careIncidence of adverse outcomes (oxygen therapy, systemic corticosteroids, hospitalisation, mechanical ventilation and mortality) in symptomatic patients at 28 days after study inclusion500September 2021January 2022Vietnam

#: Trial ongoing as of 11 January 2022 (date accessed). : Date on which this record was first entered in the EudraCT database. +: Date of first enrolment (India). GP: general practitioner.