Oligonucleotides for Gram-negative respiratory infections
| Gene silenced and typical function | Silencing clinical result | Development phase | Bacterial target | |
| CTX-M-15 ASO | blaCTX−M-15 Encodes resistance to third-generation cephalosporins | Reduced MIC to third-generation cephalosporins | Pre-clinical | E. coli; other Gram-negatives |
| MexB siRNA | mexB Encodes efflux pump component | Restored activity of resistant antibiotics | Pre-clinical | E. coli; other Gram-negatives |
| NDM-1 ASO | blaNDM-1 Encodes carbapenemases | Restored activity of resistant antibiotics | Pre-clinical | P. aeruginosa; other Gram-negatives |
NDM: New Delhi metallo-β-lactamases; MIC: minimum inhibitory concentration; E. coli: Escherichia coli; P. aeruginosa: Pseudomonas aeruginosa.