TABLE 4

Monoclonal antibody treatment options for Gram-negative respiratory infections

TargetGram-negative target(s)Development phaseStudied place in therapy
A1102LPS-O-antigen D-galactan-IIIK. pneumoniaePre-clinicalPrevention
A1124LPS-O-antigen o25bE. coliPre-clinicalPrevention
AR-101LPS 011 exopolysaccharideP. aeruginosaPhase IITreatment
AR-105Alginate exopolysaccharideP. aeruginosaPhase IIPrevention and treatment
Anti-Hyr1Hyr1 peptide 5A. baumannii and K. pneumoniaePre-clinicalPrevention
KB001-APcrv proteinP. aeruginosaPhase II/IIIPrevention
MEDI3902Pcrv protein and Psl exopolysaccharideP. aeruginosaPhase IIPrevention

LPS: lipopolysaccharide; K. pneumoniae: Klebsiella pneumoniae; E. coli: Escherichia coli; P. aeruginosa: Pseudomonas aeruginosa; A. baumannii: Acinetobacter baumannii.