Outcomes of transbronchial lung cryobiopsy (TBLC) of the included studies
| Method of diagnosis | First author (year) [ref.] | Biopsy method (n) | Diagnostic yield, % | Mortality, n (%) | Pneumothorax, n (%) | Chest drain, n (%) | Bleeding, n (%) | ILD acute exacerbation, n (%) | ||
| Mild | Moderate | Severe | ||||||||
| Histology | ||||||||||
| Hernández-González (2015) [43] | TBLC (33) | 79.0 | na | 4 (12) | 1 (3.0) | 3 (9.0) | 7 (21) | 0 (0.0) | na | |
| Ravaglia (2016) [60] | TBLC (297) | 82.8 | 1 (0.3) | 60 (20.2) | 46 (15.5) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (0.3) | |
| Linhas (2017) [25] | TBLC (90) | na | 0 (0.0) | 22 (22.4) | 18 (20.0) | 8 (8.9) | 5 (5.6) | 0 (0.0) | 0 (0.0) | |
| Lentz (2018) [47] | TBLC (104) | 44.2 | 0 (0.0) | 3 (3.0) | 3 (3.0) | 100 (96.0) | 0 (0.0) | 4 (4.0) | na | |
| Cooley (2018) [26] | TBLC (159) | 69.0 | 0 (0.0) | 17 (11.0) | 14 (8.8) | 0 (0.0) | 6 (3.8)# | na | ||
| Hagmeyer (2019) [30] | TBLC (61) | 82.0 | 2 (3.2) | 10 (16.4) | na | na | 7 (14.5) | 8 (13.1) | 2 (3.2) | |
| Harari (2019) [29] | TBLC (73) | 88.0 | na | 8 (10.9) | 2 (2.7) | 6 (19.0) | 0 (0.0) | 1 (1.4) | na | |
| Romagnoli (2019) [62] | TBLC (21) | 81.0 | na | 2 (9.5) | 1 (4.8) | na | na | na | 1 (4.8) | |
| Samitas (2019) [15] | TBLC (50) | 80.0 | na | 5 (10.0) | 0 (0.0) | 19 (38.0) | 12 (24.0) | 0 (0.0) | 0 (0.0) | |
| Cho (2019) [24] | TBLC (40) | 85.0 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 36 (90.0) | 2 (5.0) | 2 (5.0) | na | |
| Abdelghani (2019) [28] | TBLC (40) | 92.5 | 1 (1.3) | 2 (5.0) | 2 (5.0) | 6 (15.0) | 5 (8.3) | 0 (0.0) | na | |
| Hetzel (2019) [18] | TBLC (359) | na | 1 (0.3) | 27 (7.5) | na | 203 (56.5) | 54 (15.0) | 4 (1.1) | na | |
| Troy (2020) [61] | TBLC (65) | 90.0 | 1 (2.0) | 1 (4.0) | na | 14 (22.0)¶ | 0 (0.0) | 2 (3.1) | ||
| Aburto (2020) [38] | TBLC (257) | 80.2 | 0 (0.0) | 5 (2.0) | na | 18 (7.0)+ | 1 (0.4) | |||
| Bondue (2020) [35] | TBLC (81) | 84.0 | na | 17 (21.0) | 9 (11.0) | 47 (58.0) | 25 (31.0) | 4 (5.0) | 1 (1.2) | |
| Koslow (2020) [34] | TBLC (120) | 52.4 | 2 (1.6) | 6 (5.0) | 1 (0.9) | na | 8 (7.0)# | 1 (0.8) | ||
| Pajares (2020) [36] | TBLC (124) | 54.8 | na | 3 (2.4) | 2 (1.6) | 72 (60.0) | 8 (6.5) | 1 (0.8) | na | |
| Gnass (2020) [39] | TBLC (114) | 79.0 | na | 5 (4.4) | 5 (4.4) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| Wang (2020) [37] | TBLC (70) | 68.6 | 1 (1.4) | 3 (4.3) | 3 (4.3) | 0 (0.0) | 0 (0.0) | 4 (5.7) | 0 (0.0) | |
| MDD | ||||||||||
| Fruchter (2014) [42] | TBLC (75) | 70.0 | na | 2 (2.7) | 0 (0.0) | 3 (4.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| Griff (2014) [33] | TBLC (52) | 79.0 | 0 (0.0) | 0 (0.0) | 0 (0.0) | na | na | 0 (0.0) | na | |
| Pajares (2014) [41] | TBLC (39) | 51.4 | na | 3 (7.7) | na | 12 (30.8) | 22 (56.4) | 0 (0.0) | 0 (0.0) | |
| Hernández-González (2015) [43] | TBLC (33) | 79.0 | na | 4 (12) | 1 (3.0) | 3 (9.0) | 7 (21) | 0 (0.0) | na | |
| Cascante (2016) [46] | TBLC (55) | 87.3 | 0 (0.0) | 8 (14.5) | 7 (12.7) | 4 (7.3) | 1 (1.8) | 1 (1.8) | na | |
| Ramaswamy (2016) [45] | TBLC (56) | 66.0 | na | 11 (20) | na | na | na | 1 (2.0) | 0 (0.0) | |
| Kronborg-White (2017) [44] | TBLC (38) | 74.0 | na | 10 (26) | 8 (21.0) | na | 6 (15.0) | 1 (3.0) | 0 (0.0) | |
| Bango-Álvarez (2017) [23] | TBLC (106) | 86.0 | 0 (0.0) | 5 (4.7) | 2 (1.9) | 89 (84.0) | 17 (16) | 0 (0.0) | 0 (0.0) | |
| Lentz (2018) [47] | TBLC (104) | 68.3 | 0 (0.0) | 3 (3.0) | 3 (3.0) | 100 (96.0) | 0 (0.0) | 4 (4.0) | na | |
| Cooley (2018) [26] | TBLC (159) | 79.0 | 0 (0.0) | 17 (11.0) | 14 (8.8) | 0 (0.0) | 6 (3.8)# | na | ||
| Dhooria (2018) [27] | TBLC (128) | 78.1 | 4 (3.1) | 14 (10.9) | 11 (8.6) | 13 (10.2) | 4 (3.1) | 3 (2.3) | 3 (2.3) | |
| Hagmeyer (2019) [30] | TBLC (61) | 75.0 | 2 (3.2) | 10 (16.4) | na | na | 7 (14.5) | 8 (13.1) | 2 (3.2) | |
| Harari (2019) [29] | TBLC (73) | 94.5 | na | 8 (10.9) | 2 (2.7) | 6 (19.0) | 0 (0.0) | 1 (1.4) | na | |
| Romagnoli (2019) [62] | TBLC (21) | 42.9 | na | 2 (9.5) | 1 (4.8) | na | na | na | 1 (4.8) | |
| Samitas (2019) [15] | TBLC (50) | 76.0 | na | 5 (10.0) | 0 (0.0) | 19 (38.0) | 12 (24.0) | 0 (0.0) | 0 (0.0) | |
| Shafiek (2019) [32] | TBLC (12) | 83.3 | na | 0 (0.0) | 0 (0.0) | 1 (8.3) | 0 (0.0) | 0 (0.0) | na | |
| Çirak (2020) [31] | TBLC (82) | 91.5 | na | 6 (7.3) | 0 (0.0) | 23 (28.4) | 15 (18.3) | 1 (1.21) | na | |
| Troy (2020) [61] | TBLC (65) | 60.0 | 1 (2.0) | 1 (4.0) | na | 14 (22.0)¶ | 0 (0.0) | 2 (3.1) | ||
| Aburto (2020) [38] | TBLC (257) | 90.3 | 0 (0.0) | 5 (2.0) | na | 18 (7.0)+ | 1 (0.4) | |||
| Bondue (2020) [35] | TBLC (81) | 74.0 | na | 17 (21.0) | 9 (11.0) | 47 (58.0) | 25 (31.0) | 4 (5.0) | 1 (1.2) | |
| Hussein (2020) [40] | TBLC (23) | 95.6 | 0 (0.0) | 2 (8.7) | 1 (4.3) | 0 (0.0) | 0 (0.0) | 1 (4.4) | 0 (0.0) | |
| Koslow (2020) [34] | TBLC (120) | 55.0 | 2 (1.6) | 6 (5.0) | 1 (0.9) | na | 8 (7.0)# | 1 (0.8) | ||
| Pajares (2020) [36] | TBLC (124) | 47.6 | na | 3 (2.4) | 2 (1.6) | 72 (60.00) | 8 (6.5) | 1 (0.8) | na | |
ILD: interstitial lung disease; MDD: multidisciplinary discussion; na: not available. #: classified as moderate/severe; ¶: classified as mild/moderate; +: bleeding not classified by severity.