Prone positioning in non-intubated, non-coronavirus disease 2019 patients

First author [ref.]Patients nDiseasesRespiratory devicePP regimenMain resultsAdverse eventComments
Chaisupamongkollarp [19]17PneumoniaOxygenImprove SpO2
Improve compliance
Tulleken [20]1PneumoniaHFNC20 hImprove PaO2
Resolve opacities
Valter [21]4CHF, pneumonia, ARDS01–5 hImprove PaO2
Avoid intubation
01 death (CHF)
Feltracco [22]2Post-reimplantation syndromeNIV6–8 h per day,
8–10 days
Decrease FIO2
NIV removal
Feltracco [23]3Lung transplant respiratory complicationsHFPV1–3 h,
3–6 times per day
Improve secretions clearance
Improve respiratory mechanic
Attenuate graft infiltrates
Improve gas exchange
Scaravilli [24]15Hypoxaemic acute respiratory failure (pneumonia, fascitis, sepsis)HFNC, CPAP and NIV3 h per day,
2 days
Improve PaO2Intolerance (n=2)Retrospective
PaO2 return to baseline after resupination
Ding [25]20Infectious, moderate-to-severe ARDS (pneumonia, influenza)NIV and HFNC30 min twice per day,
≥3 days
Avoid intubation
Improve PaO2/FIO2
Intolerance (n=2)Intubation in 78% of severe ARDS patients
Pérez-Nieto [26]6Non-infectious, severe ARDS (thoracic trauma, lupus pneumonitis)NIV and HFNC2–3 h per 12 h,
2 days
Avoid intubation0Retrospective

PP: prone positioning; SpO2: oxygen saturation measured by pulse oximetry; HFNC: high-flow nasal cannula; PaO2: arterial oxygen tension; CHF: congestive heart failure; ARDS: acute respiratory distress syndrome; NIV: noninvasive ventilation; FIO2: inspiratory oxygen fraction; HFPV: high-frequency percussive ventilation; CPAP: continuous positive airway pressure.