Considerations in the multidisciplinary decision about locally definitive treatment
| Surgery | Radiotherapy | Combined |
| Adequate functional status | Multilevel or bulky N2 | Local tumour control is very important |
| Bulky, necrotic tumours with possible complications | (Small) tumours with multiple mediastinal lymph node involvement | Locally invasive tumours with slim possible resection margins (e.g. superior sulcus tumours) |
| Multiple nodules in the same lobe | Reasonable dose affections of lung and heart | |
| No pneumonectomy necessary | PD-L1 inhibition possible |
PD-L1: programmed death ligand 1.