Considerations in the multidisciplinary decision about locally definitive treatment

Adequate functional statusMultilevel or bulky N2Local tumour control is very important
Bulky, necrotic tumours with possible complications(Small) tumours with multiple mediastinal lymph node involvementLocally invasive tumours with slim possible resection margins (e.g. superior sulcus tumours)
Multiple nodules in the same lobeReasonable dose affections of lung and heart
No pneumonectomy necessaryPD-L1 inhibition possible

PD-L1: programmed death ligand 1.