Exercise tolerance variables: comparison between patients with COPD-nonPH versus patients with COPD-PH
| First author [ref.] | Participants | Sample size n | V′O2peak mL·Kg−1·min−1 | Wmax W | O2 pulse mL·beat−1 | V′E L·min−1 | V′E/V′CO2 slope | Ventilatory reserve % |
| Studies without lung transplant candidates | ||||||||
| Holverda [21] | COPD-nonPH | 15 | 13±3.8 | 65±25 | 7.6±1.6 | 37±10 | 36±11 | NR |
| COPD-PH | 10 | 13.2±5.1 | 47±20 | 6.6±2.4 | 46±24 | 51±23 | NR | |
| Boerrigter [18] | COPD-nonPH | 24 | 14±4.2 | 71±47 | 8.3±3.0 | 40.8±13 | NR | 22.9±20.7 |
| COPD-PH | 23 | 9.8±2.9 | 36±26 | 6.8±2.5 | 34.7±16.3 | NR | 33.1±17.0 | |
| Skjørten [28] | COPD-nonPH | 71 | 17.6±4.3 | 72±31 | 9.4±2.9 | 46±15 | NR | 9±22 |
| COPD-PH | 22 | 13.9±3 | 40±21 | 7.5±2.1 | 35±12 | NR | −7±19 | |
| Xiong [29] | COPD-nonPH | 98 | 20.4±7.2 | NR | NR | NR | NR | NR |
| COPD-PH | 82 | 14.6±6.5 | NR | NR | NR | NR | NR | |
| Blanco [10] | COPD-nonPH | 109 | 15±3 | 68±27 | 9.4±2.5 | 46±15 | NR | 12.3±21.3 |
| COPD-PH | 65 | 10±2 | 43±20 | 6.5±2.1 | 31±11 | NR | 5.9±24.8 | |
| Studies with lung transplant candidates | ||||||||
| Thirapatarapong [11] | COPD-nonPH | 67 | 11.3±4.1 | 21±15 | 5.2±1.7 | 22±10 | 36±8 | 17 (11–25) |
| COPD-PH | 31 | 9.5±2.5 | 15±9 | 5.0±1.7 | 18±7 | 36±7 | 13 (−2–25) | |
| Adir [12] | COPD-nonPH | 20 | 9.5±2.9 | 35.7±19 | 5.5±2.1 | 26±6.4 | 44.1±7.8 | 13.5±15.0 |
| COPD-PH | 24 | 9.3±2.3 | 40.4±20.4 | 5.7±2.3 | 27.9±13.1 | 37.6±7.3 | 19.4±28.3 | |
Data are presented as mean±sd or median (interquartile range), unless otherwise stated. V′O2peak: peak oxygen uptake; Wmax: maximum workload; V′E: minute ventilation; V′E/V′CO2: minute ventilation/carbon dioxide production; PH: pulmonary hypertension; NR: not reported.