First author [ref.] | Fatigue assessment tool | Sample size n | Responder | Responders with fatigue | Normal | Mild | Severe | Comments |
Peters#,¶ [14] | CIS – subscale fatigue | 168 | Patients with COPD | 54 | 25 | 21 | ||
Baltzan+ [30] | SF-36 – vitality domain | 251 | Patients with COPD | 61 | 39 | Patients were divided into 2 groups based on scores <2 sd from published mean age-adjusted normal vitality scores for general Canadian population | ||
Walke#,§ [23] | ESAS –tiredness/fatigue symptom | 74 | Patients with COPD | 31 | 19 | 50 | Normal fatigue is not reported in study; it is calculated for this table by subtracting % of “mild” and “severe” fatigue from possible total of 100% Original VAS score modified so symptoms rated on 4-point scale (not present, mild, moderate, severe) Only “moderate” and “severe” symptoms examined here | |
Yang# [24] | FACIT – fatigue scale | 210 | Patients with COPD | 51 | 31 | 17 | ||
Goërtz#,¶ [27] | CIS – subscale fatigue | 1290 199 | Patients with COPD Non-COPD subjects | 25 75 | 26 17 | 49 10 | ||
Andersson# [29] | FACIT – fatigue scale | 470 659 | Patients with COPD Non-COPD subjects | 43 39 | ||||
Kentson# [16] | 3 structured questions on fatigue | 73 19 | Patients with COPD Non-COPD subjects | 72 56 | Subjects reporting fatigue scores ≥1 were classified as “fatigue”; scores of 0 as “no fatigue” | |||
Theander# [28] | FIS – all dimensions | 44 37 | Patients with COPD Non-COPD subjects | 47 13 | Information on cut-off scores not reported. COPD patients report ↑ impact of fatigue on cognitive, physical and psychosocial functioning in comparison to controls | |||
Vandevoordeƒ [20] | One item on fatigue | 68 78 | All COPD Patients with known COPD Patients with newly detected COPD Non-COPD subjects | 47 35 47 | ||||
Strandkvist# [33] | FACIT – fatigue scale | 304 362 | Patients with COPD: women Patients with COPD: men Non-COPD subjects: women Non-COPD subjects: men | 36 38 28 28 | Prevalence of clinically relevant fatigue only significant between male subjects with and without COPD (p=0.016) Clinically relevant fatigue defined as FACIT-Fatigue score of ≤43 | |||
Stridsman# [32] | FACIT – fatigue scale | 367 418 | Patients with COPD Non-COPD subjects | 37 28 | Clinically relevant fatigue was defined as FACIT-Fatigue score of ≤43 | |||
Stridsman# [31] | FACIT – fatigue scale | 261 307 | Patients with COPD Non-COPD subjects | 46 39 | Clinically significant difference was identified by 3–4 unit change in score | |||
Antoniu# [35] | SF-36 – vitality domain | 12 | Patients with COPD | 60 | Clinically significant fatigue was defined as score ≤50 | |||
Gift# [21] | SF-36 – vitality domain | 104 | Patients with COPD | 58 | Number calculated by % responders who gave a positive answer to question about feeling a lack of energy during the past week | |||
Elbehairy## [39] | ESAS-r – tiredness/fatigue symptom | 45 | Patients with COPD | 49 | Number reflects patients with COPD reporting a score of ≥5 on “Tiredness” symptom | |||
Antoniu# [34] | ESAS-r – tiredness/fatigue symptom | 47 | Patients with COPD | 95 | Fatigue considered as clinically significant, bothersome for patient if scored ≥4 | |||
Walke#,§ [22] | ESAS-r – tiredness/fatigue symptom | 81 | Patients with COPD | 49 | Original VAS score modified so that symptoms rated on 4-point scale (not present, mild, moderate, severe) Only “moderate” and “severe” symptoms were examined | |||
Chen+ [39] | BFI | 91 | Patients with COPD | 77 | Information on cut-off scores not reported | |||
Bentsen## [33] | BPQ – fatigue item | 100 | Patients with COPD | 72 | ||||
Valderramas# [25] | FSS | 30 | 60 | |||||
Wong+ [32] | MFI – all dimensions | 42 | Mental fatigue General fatigue Physical fatigue Reduced activity Reduced motivation | 69 54 95 88 83 | Information on cut-off scores not reported | |||
Blinderman# [26] | MSAS – lack of energy symptom | 100 | Patients with COPD | 71 | Number calculated by taking % of patients reporting scores of 3 or 4 on a scale of 0–4 | |||
Kinsman#,## [34] | BESC – fatigue scale | 146 | Patients with COPD | 95 |
Data are presented as %, unless otherwise stated. CIS: Checklist Individual Strength; SF-36: 36-item Short-Form Health Survey; ESAS: Edmonton Symptom Assessment Scale; VAS: visual analogue score; FACIT: Functional Assessment of Chronic Illness Therapy – Fatigue Scale; FIS: Fatigue Impact Scale; BFI: Brief Fatigue Inventory; BPQ: Breathing Problem Questionnaire; FSS: Fatigue Severity Scale; MFI: Multidimensional Fatigue Inventory; MSAS: Memorial Symptom Assessment Scale; BESC: Bronchitis–Emphysema Symptom Checklist. #: secondary care population; ¶: data partially obtained from the same set of data; +: pulmonary rehabilitation population; §: data obtained from the same set of data; ƒ: primary care population; ##: tertiary care population.