Description of included studies and risk of bias assessment
| Study/year/n | PERT group number | Control group number | Location | Study design/control definition | Types of PE included in PERT | Risk of bias score |
| Kabrhel et al. 2016 [14] (n=314) | 314 | NA | USA | Case series/NA | All PE | 15; IHE# |
| Sista et al. 2017 [20] (n=87) | 87 | NA | USA | Case series/NA | All PE | 15; IHE |
| Mahar et al. 2018 [17] (n=118) | 118 | NA | USA | Case series/NA | All PE | 13; IHE |
| Chaudhury et al. 2019 [5] (n=769) | 426 | 343 | USA | Cohort/historical cohort | All PE | 7; Newcastle¶ |
| Jen et al. 2019 [13] (n=321) | 167 | 154 | Singapore | Cohort/historical cohort | All PE | 7; Newcastle |
| Wright et al. 2019 [24] (n=305) | 146 | 159 | USA | Cohort/historical cohort | Intermediate/high risk | 7; Newcastle |
| Xenos et al. 2019 [25] (n=1069) | 77 | 992 | USA | Cohort/historical cohort | All PE | 8; Newcastle |
| Annabathula et al. 2020 [12] (n=530) | 304 | 226 | USA | Cohort/historical cohort | All PE | 7; Newcastle |
| Carroll et al. 2020 [6] (n=2042) | 1158 | 884 | USA | Cohort/historical cohort | All PE | 9; Newcastle |
| Khaing et al. 2020 [15] (n=52) | 52 | NA | USA | Case series/NA | Intermediate/high risk | 17; IHE |
| Kwok et al. 2020 [16] (n=141) | 60 | 81 | USA | Cohort/no PERT activation | All PE | 7; Newcastle |
| Melamed et al. 2020 [21] (n=1105) | 411 | 694 | USA | Cohort/historical cohort with treatment algorithm | All PE | 6; Newcastle |
| Myc et al. 2020 [18] (n=554) | 120 | 434 | USA | Cohort/historical cohort and no PERT activation | All PE | 7; Newcastle |
| Romano et al. 2020 [19] (n=128) | 128 | NA | Canada | Case series/NA | Intermediate/high risk | 15; IHE |
| Sławek-Szmyt et al. 2020 [22] (n=80) | 80 | NA | Poland | Prospective case series | All PE | 15; IHE |
| Wiske et al. 2020 [23] (n=179) | 179 | NA | USA | Case series/NA | Intermediate/high risk | 13; IHE |
NA: not applicable; PE: pulmonary embolism; PERT: pulmonary embolism response team. #: Institute of Health Economics (IHE) for case series studies; maximum score is 20; higher score, less risk of bias and higher quality. ¶: Newcastle Ottawa for cohort studies; maximum score is 9; higher score, less risk of bias and higher quality.