Drug–drug interaction (DDI) potency classification, reflecting the approach used for recommendations in figure 1

ColourDDI potency classification
GreenNo relevant interaction, combination is expected to be safe.
YellowInteraction of weak magnitude, relevance unclear or unlikely. No a priori dose adjustment of the DOAC required.
AmberInteraction of moderate-potent magnitude, requiring an a priori dose or administration time adjustment of the DOAC.
RedInteraction of potent magnitude which cannot be managed by a dose adjustment. Co-administration should be avoided as it can have deleterious consequences.

Choosing the DDI with the lowest classification is recommended (see “General recommendations” section). DOAC: direct oral anticoagulant. Adapted from [25].