TABLE 1

Drug–drug interaction (DDI) potency classification, reflecting the approach used for recommendations in figure 1

 Colour DDI potency classification Green No relevant interaction, combination is expected to be safe. Yellow Interaction of weak magnitude, relevance unclear or unlikely. No a priori dose adjustment of the DOAC required. Amber Interaction of moderate-potent magnitude, requiring an a priori dose or administration time adjustment of the DOAC. Red Interaction of potent magnitude which cannot be managed by a dose adjustment. Co-administration should be avoided as it can have deleterious consequences.

Choosing the DDI with the lowest classification is recommended (see “General recommendations” section). DOAC: direct oral anticoagulant. Adapted from [25].