ILA progression | Mortality | First author [ref.] | |
Age, years | OR 1.14 (95% CI 1.11–1.17) | Araki [15] | |
MUC5B (rs35705950) | OR 2.8 (95% CI 1.7–4.4) | Araki [15] | |
Progressive ILA | HR 3.9 (95% CI 1.3–10.9) | Araki [15] | |
HRCT predictors | |||
Subpleural reticular markings | OR 6.6 (95% CI 2.3–19) | OR 1.6 (95% CI 1.0–2.5) | Putman [31] |
Traction bronchiectasis | OR 6.6 (95% CI 2.3–19) | OR 1.6 (95% CI 1.3–2.1) | Putman [31] |
Traction bronchiectasis score 1 | HR 2.18 (median OS 8.5 years) | Hida [32] | |
Traction bronchiectasis score 2 | HR 2.65 (median OS 7.7 years) | Hida [32] | |
Traction bronchiectasis score 3 | HR 6.8 (median OS 5.4 years) | Hida [32] | |
Subpleural location | OR 6.6 (95% CI 2.3–19) | OR 1.6 (95% CI 1.0–2.7) | Putman [31] |
Lower lobes predominant changes | OR 6.7 (95% CI 1.8–25) | ns | Putman [31] |
Indeterminate for UIP | ns | Putman [31] | |
Probable UIP | OR 1.9 (95% CI 1.5–2.5) | Putman [31] | |
Definite UIP | OR 4.5 (95% CI 2.8–7.2) | Putman [31] |
Traction bronchiectasis score: 0=absence; 1=bronchiolectasis only; 2=mild moderate traction bronchiectasis; 3=severe traction bronchiectasis and/or honeycombing. OR and hazard ratio (HR) on adjusted multivariable analysis. HCRT: high-resolution computed tomography; HR: hazard ratio; ns: nonsignificant when p>0.05; OS: overall survival; UIP: usual interstitial pneumonia.