First diagnosis
| Statement number | Statement | Type of statement | Strength of recommendation | Quality of evidence | Type of patient | Most relevant supporting articles |
| 1.1 | In infants diagnosed via newborn screening, CT can be used as a sensitive tool to detect early disease, tailor treatment, and monitor disease progression both in symptomatic and asymptomatic patients. | Recommendation | Grade B | Moderate | Asymptomatic and symptomatic | [10, 13, 29, 30] |
| 1.2 | Low-dose CT is feasible both in uncooperative and cooperative patients. | Recommendation | Grade A | High | Asymptomatic and symptomatic | [31–36] |
| 1.3 | Although MRI is more feasible in cooperative patients, it can be performed in uncooperative patients with or without moderate sedation/general anaesthesia according to the patient's age and mental status. | Recommendation | Grade B | Moderate | Asymptomatic and symptomatic | [7–9, 28, 33, 37–39] |
| 1.4 | CT dose should be as low as reasonably achievable without affecting the diagnostic quality of the image. | Recommendation | Grade A | High | Asymptomatic and symptomatic | [14, 40–44] |
CT: computed tomography; MRI: magnetic resonance imaging.