TABLE 2

Causes of pulmonary hypertension in sarcoidosis patients

ConditionPotential treatments
Vascular disease
 VasculitisGlucocorticoids and other anti-inflammatory treatments
Pulmonary vasodilators
 Granulomatous vascular involvementGlucocorticoids and other anti-inflammatory treatments
Pulmonary vasodilators
 Veno-occlusive diseaseGlucocorticoids and other anti-inflammatory treatments
Careful use of pulmonary vasodilators
 Pulmonary embolism (CTEPH)Anticoagulation
Balloon pulmonary angioplasty
Pulmonary endarterectomy
Pulmonary vasodilators
Interstitial lung disease
 Parenchymal lung disease due to granulomasGlucocorticoids and other anti-inflammatory treatments
 Parenchymal lung disease due to fibrosisAnti-fibrotic agents
 Hilar and mediastinal distortion
 Pulmonary artery/vein extrinsic compressionGlucocorticoids and other anti-inflammatory treatments
Dilation and/or stenting of compressed vessels
 Fibrosing mediastinitisDilation and/or stenting of compressed vessels
Extrapulmonary disease
 Left ventricular systolic dysfunctionGlucocorticoids and other anti-inflammatory treatments
Diuretics, afterload reduction
 Left ventricular diastolic dysfunctionDiuretics
 Sleep apnoeaCPAP, oxygen and other measures
 Liver diseaseGlucocorticoids and other anti-inflammatory treatments

CTEPH: chronic thromboembolic pulmonary hypertension; CPAP: continuous positive airway pressure.