Noninvasive PH markers

  • Cardiac functional impairment

  •  Echocardiography

  •  Cardiac magnetic resonance

  • PH severity evaluation

  •  Echocardiography

  • Cardiac stress

  •  BNP

  • Morphologic consequences

  •  PA dilatation on CT

  • Global functional consequences

  •  6MWD

  •  Oxygen desaturation during 6MWD

  •  Heart rate recovery

  • Pulmonary function vasculopathy profiles

  •  Severe reduction in DLCO

  • DLCO reduction that is disproportionate to reductions in lung volumes – KCO, the DLCO/FVC ratio

PH: pulmonary hypertension; BNP: B-type natriuretic peptide; PA: pulmonary artery; CT: computed tomography; 6MWD: 6-min walk distance; DLCO: diffusing capacity of the lung for carbon monoxide; KCO: transfer coefficient of the lung for carbon monoxide; FVC: forced vital capacity.