General findings from studies investigating gender differences in pulmonary arterial hypertension (PAH)

Females with PAH compared to males
 ↑ susceptibility to PAH development
 ↑ pulmonary vascular remodelling
 ↑ right ventricle contractility and ejection fraction
 ↓ haemodynamic alterations
 ↑ response to treatment with endothelin receptor antagonists
 ↑ improvement in right ventricle ejection fraction after PAH treatment
 ↑ survival