General findings from studies investigating gender differences in pulmonary arterial hypertension (PAH)
| Females with PAH compared to males |
| ↑ susceptibility to PAH development ↑ pulmonary vascular remodelling ↑ right ventricle contractility and ejection fraction ↓ haemodynamic alterations ↑ response to treatment with endothelin receptor antagonists ↑ improvement in right ventricle ejection fraction after PAH treatment ↑ survival |