TP53-associated genetic susceptibility to lung cancer: criteria for referral to the cancer genetics clinic for genetic counselling and germline testing
| 1. Lung adenocarcinoma age <46 years regardless of smoking history and |
| personal history of pre-menopausal breast cancer, glioma, sarcoma, adrenocortical carcinoma, acute leukaemia, choroid plexus tumour, OR |
| family history in first- or second-degree relatives of pre-menopausal breast cancer, glioma, sarcoma, adrenocortical carcinoma, acute leukaemia, choroid plexus tumour, lung adenocarcinoma age <56 years |
| 2. Lung adenocarcinoma age <50 years with a somatic EGFR-activating variant or deletion, regardless of smoking and family history |
Information from [16].