TABLE 3

Classification of immunoglobulin G4-related disease (IgG4-RD) thoracic involvement according to the criteria of Corcoran et al. [6]

Category of thoracic involvementNumber of patients (group 1/group2)Thoracic patternsAge at diagnosis, years median±sdMale n/N (%)Elevated serum IgG4 level n/N (%)Smoking history >10 pack years n/N (%)Industrial or environmental exposure to asbestos n/N (%)
Definite
Biopsy proved thoracic involvement
23/4815 lymph node enlargement
13 peribronchovascular involvements
Seven nodular
Four interstitial disease
Two GGO
59±1420/23 (87)20/23 (87)3/23 (13)0/23 (0)
Highly probable
Typical radiology with no alternative explanation and response to treatment
9/48Seven peribronchovascular involvement
Four lymph node enlargement
Three GGO
One nodular
One interstitial disease
49±178/9 (89)8/9 (89)1/9 (11)0/9 (0)
Probable
Typical radiology with no alternative explanation
15/48Eight peribronchovascular involvements
Three lymph node enlargement
Three nodular
65±1610/15 (66)14/15 (93)3/15 (20)0/15 (0)
Possible
Radiology potentially consistent with IgG4-RD but plausible alternative cause identified
1/48One interstitial disease761/1 (100)1/1 (100)0/1 (0)1/1 (100)

GGO: ground-glass opacity; sd: standard deviation.