TABLE 1

Characteristics of included studies

First author [ref.]Total sample sizeCountryDefinition of chronic coughStudy type
Adams [24]3960AustraliaCough lasting >12 weeksProspective cohort study
Baiardini [8]166ItalyCough lasting >3 weeksStudy addressing item generation of a PROM (Chronic Cough Impact Questionnaire)
Birring [7]104UKCough lasting >3 weeksStudy addressing item generation of a PROM (Leicester Cough Questionnaire)
Campi [25]1204ItalyCough lasting >8 weeksCross-sectional study
Chamberlain [26]1120UK, Germany, France, Italy, Poland, Russia, Ukraine, Latvia, Lithuania, Moldova, Romania, Bulgaria, Turkey, Greece, Czech Republic, Austria, Switzerland, Spain, Portugal, Ireland, Iceland, Norway, Sweden, Belgium, Netherlands, Denmark, Cyprus, LuxembourgCough lasting >8 weeksCross-sectional study
Chan [27]55AustraliaCough lasting >8 weeksCross-sectional study
Cheng [28]176CanadaNRCross-sectional study
Çolak [29]14 740DenmarkCough lasting >8 weeksProspective cohort study
Çolak [30]14 669DenmarkCough lasting >8 weeksProspective cohort study
Cornford [31]30USACough lasting >3 weeks and who consulted due to cough as the primary illnessQualitative study
Crawford [32]41Germany, Spain, France, Japan, USADaily cough and sputum production >3 monthsStudy addressing item generation of a PROM (Cough and Sputum Assessment Questionnaire)
Decalmer [33]62UKCough lasting >8 weeksCross-sectional study
Everett [34]373UKNRCross-sectional study
Everett [35]47UKDemonstrable abnormality of oesophageal manometry or PH monitoring or bothCross-sectional study
Faruqi [36]86UK, USA, Japan, GermanyNAQualitative study
Faruqi [37]25UKCough lasting >6 monthsProspective cohort study
Ford [38]3883UKCough lasting >8 weeksCross-sectional study
French [39]80USACough lasting >8 weeksProspective cohort study
French [40]39USACough lasting >3 weeksProspective cohort study; study addressing item generation of a PROM (Cough-Specific Quality of Life Questionnaire)
Fujimura [41]1000JapanCough lasting >8 weeksQualitative study
Hilton [42]100UKCough lasting >8 weeksCross-sectional study
Hsu [14]47UKCough lasting >6 monthsStudy addressing item generation of a PROM (Cough Symptom Score)
Hulme [43]14UKCough lasting >8 weeksQualitative study
Kang [44]447KoreaCough lasting >8 weeksCross-sectional study
Kelsall [45]62UKCough lasting >8 weeksCross-sectional study
Kelsall [46]70UKCough lasting >8 weeksCross-sectional study
Koo [10]401KoreaCough lasting >8 weeksStudy addressing item generation of a PROM (Cough Assessment Test)
Koskela [47]3697FinlandCough lasting >8 weeksCross-sectional study
Koskela [48]3695FinlandCough lasting >8 weeksCross-sectional study
Kuznair [49]136USACough lasting >3 weeksCross-sectional study
Lai [50]1162ChinaCough lasting >8 weeksCross-sectional study
Lan [51]164AustraliaCough lasting >8 weeksCross-sectional study
Landt [52]41 545DenmarkCough lasting >8 weeksProspective cohort study
Lätti [53]3673FinlandCough lasting >8 weeksCross-sectional study
Lee [54]49UKCough lasting >8 weeksCross-sectional study
Lee [55]100UKCough lasting >8 weeksCross-sectional study
Lee [56]32UKCough lasting >8 weeksCross-sectional study
Ma [57]200ChinaCough lasting >8 weeksProspective cohort study
Mello [58]88USACough lasting >3 weeksCross-sectional study
Morice [59]255UKCough lasting >8 weeksStudy addressing item generation of a PROM (Hull Airway Reflux Questionnaire)
Murry [60]16USANRRetrospective cohort study
Ojoo [61]112UKCough lasting >8 weeksProspective cohort study
Ozge [62]165TurkeyCough lasting >4 weeksCross-sectional study
Sato [63]129JapanNRCross-sectional study
Shariat [64]360USANRCross-sectional study
Shembel [65]365USACough lasting >8 weeksStudy addressing item generation of a PROM (Cough Severity Index)
Sinha [66]223UKCough lasting >8 weeksQualitative study
Smith [67]26UKCSS daytime cough score ≥2Cross-sectional study
Song [68]857KoreaCough lasting >12 weeksCross-sectional analysis of a prospective cohort study
Ternesten-Hasseus [69]121SwedenCough lasting >8 weeksCross-sectional study
Van de Kerkhove [70]51BelgiumCough lasting >8 weeksProspective cohort study
Vazquez [71]1422USACough lasting >2 yearsProspective cohort study
Vernon [16]22USACough lasting >8 weeksQualitative study
Vernon [15]39USACough lasting >8 weeksStudy addressing item generation of a PROM (Cough Severity Diary)
Vertigan [72]38AustraliaCough lasting >8 weeksStudy addressing item generation of a PROM (Newcastle Laryngeal Hypersensitivity Questionnaire)
Vertigan [73]171AustraliaCough lasting >8 weeksCross-sectional study
Vertigan [74]171AustraliaCough lasting >8 weeksCross-sectional study
Vertigan [75]53AustraliaCough lasting >8 weeksCross-sectional study
Won [76]478KoreaCough lasting >8 weeksCross-sectional study
Xu [77]87ChinaCough lasting >8 weeksRetrospective cohort study
Zhan [11]237ChinaCough lasting >8 weeksStudy addressing item generation of a PROM (Cough Evaluation Test)

NR: not reported; NA: not available; CSS: Cough Symptom Score; PROM: patient-reported outcome measurement.