Corticosteroids in community-acquired pneumonia (CAP) versus coronavirus disease-2019 (COVID-19)

SeverityIDSA/ATS severe CAP [11]Severe acute respiratory failure#
TimingFirst 24 hFirst 24 h
Type of steroids and dosagePrednisone (50 mg daily)
Methylprednisolone (40–80 mg daily)
Dexamethasone (5 mg daily)
Dexamethasone (6 mg daily)
Hydrocortisone (200 mg daily)
Duration5–8 days7 days
OutcomeDecrease treatment failure and mortalityDecrease mortality
HarmsIncreased readmission in one studyCAPA?

IDSA: Infectious Diseases Society of America; ATS: American Thoracic Society; CAPA: COVID-19-associated pulmonary aspergillosis. #: as defined in the RECOVERY trial [58].