TABLE 2

Summary of the studies included in systematic review and meta-analysis

First author [ref.]Country/regionStudy periodStudy designRadon detection techniqueSexPopulation sourceOutcome: LC diagnosis/deathNever-smokersEver-smokers
CasesControlsCasesControls
Darby[48]
Darby[51]
Europe1960–99Pooled studyM/FGeneral+hospitalDiagnosis884541860408252
Oberaigner[25]Austria1970–92C-CM/FGeneralDiagnosis2241159127
Tomasek[26]Czechia1960–99CohortKodak LR115M/FGeneralDeath28295143417
Auvinen [27]Finland1986–92C-CAlpha trackM/FGeneralDiagnosis44229772752
Ruosteenoja[28]Finland1979–85C-CRadon dosimeterMGeneralDiagnosis333155291
Baysson[29]France1990–99C-CKodalpha LR115M/FHospitalDiagnosis44344521797
Kreuzer[30]Germany: eastern1991–97C-CAlpha trackM/FGeneralDiagnosis96544850994
Kreienbrock[31]Germany: western1990–95C-CSolid-state nuclear trackM/FGeneralDiagnosis8965312251433
Bochicchio[32]Italy1993–96C-CRadon dosimeterM/FHospitalDiagnosis28102355291
Barros-Dios [33]Spain1992–94C-CAlpha trackM/FGeneralDiagnosis1294144133
Pershagen[34]Sweden1980–84C-CSolid-state alpha trackM/FGeneralDiagnosis1751156682761
Lagarde[35]Sweden1978–95C-CRadon dosimeterM/FGeneralDiagnosis258487
Pershagen[44]Sweden: Stockholm1983–87C-CAlpha trackFGeneral+hospitalDiagnosis36181160194
Darby[36]England1988–95C-CSmall passive radonM/FGeneral+hospitalDiagnosis268968742062
Krewski[49]
Krewski[50]
North America1982–97Pooled studyM/FGeneralDiagnosis659218529302681
Schoenberg[37]USA: New Jersey1982–84C-CAlpha trackFGeneralDiagnosis61213372189
Letourneau[38]Canada: Winnipeg1983–90C-CCR-39 alpha trackM/FGeneralDiagnosis24224509498
Alavanja[39]USA: Missouri1986–92C-CAlpha trackFGeneralDiagnosis377983161200
Alavanja[45]USA: Missouri1993–94C-CCR-39 alpha-particleFGeneralDiagnosis3162471480
Field[40]USA: Iowa1993–97C-CAlpha trackFGeneralDiagnosis56414357200
Sandler[65]USA: Connecticut1989–92C-CAlpha track etchM/FGeneralDiagnosis5478718735
Sandler[65]USA: Utah1989–92C-CAlpha track etchM/FGeneralDiagnosis56211342379
Lubin[46]
Lubin[47]
China1985–98Pooled studyM/FGeneralDiagnosis322+708+7061266
Blot[42]China: Shenyang1985–87C-CRadon dosimeterFGeneralDiagnosis113213162120
Wang[43]China: Gansu1994–98C-CAlpha trackM/FGeneralDiagnosis2094955441146
Lorenzo-Gonzalez [52]Spain: northwest2003–13Pooled studyAlpha trackM/FHospitalDiagnosis476+656+261f264f
Barros-Dios [66]Spain: Galicia2004–08C-CAlpha trackM/FHospitalDiagnosis47220261264
Torres-Duran [64]##Spain: Galicia2011–13C-CAlpha trackM/FHospitalDiagnosis192329
Wilcox[68]¶¶USA: New Jersey1989–92C-CAlpha trackM/FGeneralDiagnosis40116521513
Turner[67]¶¶USA1982–88CohortMean county-level of radonM/FGeneralDeath271375 0872733355 286

Data are presented as n. LC: lung cancer; C-C: case–control study; M: male; F: female. #: these studies are included in the meta-analysis for never-smokers; : these studies are included in the meta-analysis for ever-smokers; +: unpublished data provided by original investigators; §: this study has been revised by its lead investigator to exclude the results of Barros-Dios [33] which was included in the Darby [48] pooled study; ƒ: data for ever-smokers extracted from Barros-Dios [66] which was not analysed in the pooled study; ##: this study has been updated from July 2013 by its lead investigator to include more cases and controls in the Lorenzo-Gonzalez [52] pooling study; ¶¶: these studies are not included in the meta-analysis due to different measures of effect (cohort study) or standard errors or confidence intervals (case–control study) not reported for their risk estimates.