Diagnostic criteria of idiopathic pneumonia syndrome following haematopoietic stem cell transplantation

  • Evidence of widespread alveolar injury:

    • Multilobar infiltrates on chest imaging

    • Symptoms and signs of pneumonia

    • Increased A–a gradient, restrictive pattern on pulmonary function test

  • Absence of LRT infection after appropriate evaluation:

    • Bronchoalveolar lavage negative for bacterial and nonbacterial pathogens

    • Serological studies negative for viral and fungal infections

    • Lung biopsy if patient's condition permits and above work-up is inconclusive

  • Absence of cardiac dysfunction, acute renal failure or iatrogenic fluid overload as aetiology for pulmonary dysfunction