Serum biomarkers for prognosis in hypersensitivity pneumonitis
| First author [ref.] | Study location | Population | Subjects n | Biomarker of interest | Primary outcome | Results |
| Nukui [66] | Japan | Chronic bird-related HP | 63 | Periostin | All-cause mortality | Higher serum periostin levels are associated with worse survival (periostin >92.5ng·mL−1 mean (95% CI) survival 34.8 (25.2–44.5) months; perisostin <92.5ng·mL−1 mean (95% CI) survival 65.0 (46.0–84.1) months) |
| Long [67] | Germany | HP (11 acute/subacute, 61 chronic) | 72 | YKL-40 (serum and BALF) | Disease progression | Higher serum YKL-40 levels are associated with disease progression (cut-off 119 ng·mL−1 HR 6.567; p<0.001) |
| All-cause mortality | Higher serum YKL-40 levels are associated with worse survival (cut-off 150 ng·mL−1; HR 9.989; p<0.001) | |||||
| Miyazakai [63] | Japan | Chronic bird-related HP | 56 | CCL-17 | Incidence of acute exacerbation | Higher serum CCL-17 levels are associated with increased incidence of acute exacerbations (2-year incidence of acute exacerbations with baseline CCL-17 >285pg·mL−1 30.1%, baseline CCL-17 <285 pg·mL−1 3.3%) |
| Janssen [68] # | Netherlands | Bird-related HP | 49 | KL-6 and SP-D | Change in DLCO | Not available |
HP: hypersensitivity pneumonitis; BALF: bronchoalveolar lavage fluid; DLCO: diffusing capacity of the lung for carbon monoxide, CCL-17: C-C chemokine ligand 17, KL-6: Krebs von den lungen 6, SP-D: surfactant protein-D. #: unable to access full paper.