Serum biomarkers for prognosis in hypersensitivity pneumonitis

First author [ref.]Study locationPopulationSubjects nBiomarker of interestPrimary outcomeResults
Nukui [66]JapanChronic bird-related HP63PeriostinAll-cause mortalityHigher serum periostin levels are associated with worse survival (periostin >92.5ng·mL−1 mean (95% CI) survival 34.8 (25.2–44.5) months; perisostin <92.5ng·mL−1 mean (95% CI) survival 65.0 (46.0–84.1) months)
Long [67]GermanyHP (11 acute/subacute, 61 chronic)72YKL-40 (serum and BALF)Disease progressionHigher serum YKL-40 levels are associated with disease progression (cut-off 119 ng·mL−1 HR 6.567; p<0.001)
All-cause mortalityHigher serum YKL-40 levels
are associated with worse survival (cut-off 150 ng·mL−1; HR 9.989; p<0.001)
Miyazakai [63]JapanChronic bird-related HP56CCL-17Incidence of acute exacerbationHigher serum CCL-17 levels are associated with increased incidence of acute exacerbations (2-year incidence of acute exacerbations with baseline CCL-17 >285pg·mL−1 30.1%, baseline CCL-17 <285 pg·mL−1 3.3%)
Janssen [68] #NetherlandsBird-related HP49KL-6 and
Change in DLCONot available

HP: hypersensitivity pneumonitis; BALF: bronchoalveolar lavage fluid; DLCO: diffusing capacity of the lung for carbon monoxide, CCL-17: C-C chemokine ligand 17, KL-6: Krebs von den lungen 6, SP-D: surfactant protein-D. #: unable to access full paper.