TABLE 3

Comparison of survival time and mortality prediction scores for pulmonary arterial hypertension (PAH)

	[Ref.]		Risk assessment tools	Predictors of survival	Registry used for validation
NIH registry	[7]	IPAH	Risk equation	NYHA, RAP, PAP, CI, D_LCO
PHC registry	[6]	PAH		Age, CTD, NYHA, RAP, PAP, CI
		IPAH	Risk equation	Age, NYHA, RAP, PAP, CI
French registry	[8]	PAH			REVEAL
		IPAH	Risk equation	Sex, 6MWD, CO
REVEAL	[46]	PAH	Risk equation and risk score table	PVR, RAP, PO-PAH-FPAH-CTD, NYHA, sex, age, renal, BP, HR, 6MWD, BNP, pericardial effusion, D_LCO	French registry UK registry Spanish registry
		IPAH
Scottish/UK	[10]	PAH	Risk score	Age, sex, aetiology, 6MWD, RAP, CO	UK registry
		IPAH
UK	[47]
Spanish	[11]	PAH		Sex, NYHA, RAP, CI, CTD-PO-PAH-PVOD
		IPAH
COMPERA	[12]	IPAH		Sex, 6MWD
ESC/ERS	[36]		Risk score table		Swedish registry
					COMPERA registry French registry

NIH: National Institute of Health; PHC: Pulmonary Hypertension Connection registry; REVEAL: Registry To Evaluate Early and Long-Term Pulmonary Arterial Hypertension; COMPERA: Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension; ESC/ERS: European Society of Cardiology/European Respiratory Society; IPAH: idiopathic PAH; NYHA: New York Heart Association; RAP: right atrial pressure; PAP: pulmonary arterial pressure; CI: cardiac index; D_LCO: diffusion capacity for carbon monoxide; CTD: connective tissue disease; 6MWD: 6-min walking distance; CO: cardiac output; PVR: pulmonary vascular resistance; PO-PAH: porto-PAH; FPAH: familial PAH; BP: blood pressure; HR: heart rate; BNP: brain natriuretic peptide; PVOD: pulmonary veno-occlusive disease.