TABLE 2

Recommended doses for commonly used medications in restless legs syndrome

Initial doseMaximum dose
Pramipexole0.125 mg·day−10.50 mg·day−1
Ropinirole0.25 mg·day−14 mg·day−1
Rotigotine patch1 mg·day−13 mg·day−1
Gabapentin enacarbil600 mg·day−11200 mg·day−1
Pregabalin75 mg·day−1450 mg·day−1
Gabapentin300 mg·day−12400 mg·day−1
Methadone5–10 mg·day−120–40 mg·day−1
Oxycodone/naloxone5 mg oxycodone/ 2.5 mg naloxone twice daily20 mg oxycodone/ 10 mg naloxone twice a day
Clonazepam0.25 mg·day−12 mg·day−1