Phenotypes of obstructive sleep apnoea (OSA) patients of interest for mandibular advancement device therapy
| Phenotypes that have been related to treatment success | Phenotypes of interest to study | |
| Anthropometric | Females; younger age; less overweight/obesity | |
| Polysomnographic | Positional OSA | More sophisticated ways to interpret polysomnographic sleep recordings; simpler methods to evaluate treatment effects |
| Functional | DISE defining type of collapse and increase in airway size during advancement | |
| Symptomatic | Sleepiness and fatigue; headaches; restless legs; nasal symptoms; insomnia; disturbed sleep; minimally symptomatic | |
| Cardiovascular | Systemic hypertension; other cardiovascular diseases | |
| Metabolic/endocrine | Type 2 diabetes | |
| Other comorbidities | More overall knowledge on relationships between OSA and comorbidities |
DISE: drug-induced sleep endoscopy.