TABLE 1

Stratification of systematic reviews of interventions

Direct effect
 Evidence that intervention has a direct effect in controlling or preventing TB, i.e. preventing cases or reducing incidence, reported as a primary or secondary outcome of the review
Indirect effect
 No direct effect reported, but intervention has a plausible indirect effect in preventing TB cases or reducing TB incidence, for example via improvements in diagnosis, detection, treatment outcomes and reductions in transmission and resistance

TB: tuberculosis.