Lung function |
Rate of decline in FVC (mL·year−1) Absolute or relative changes in FVC (mL or % predicted) Absolute or relative changes in DLCO % predicted Categorical declines in FVC or DLCO (mL or % predicted)
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Exercise capacity |
Absolute change in 6-min walk test distance Categorical decline in 6-min walk test distance Change in oxygen saturation nadir during 6-min walk test
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Patient-reported outcomes |
Open question(s) on symptoms St George's Respiratory Questionnaire (SGRQ) University of California San Diego Shortness of Breath Questionnaire (UCSD-SOBQ) Cough and Sputum Assessment Questionnaire (CASA-Q) EuroQol 5-Dimensional Quality of Life Questionnaire (EQ-5D) Short-Form Health Survey (SF-36)
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Acute worsenings |
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Mortality |
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Radiological markers |
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Serum biomarkers |
Krebs von den Lungen-6 protein (KL-6) Surfactant proteins D and A Neoepitopes (biomarkers of extracellular matrix turnover)
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