TABLE 2

Intensive care unit (ICU), in-hospital and follow-up mortality in patients with mixed-interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF)

First author [ref].	Inclusion years month/year	Total⁺	Included^§	IPF	Overall deaths	ICU mortality %	In-hospital mortality %	Overall in-hospital mortality %	Follow-up mortality %
Mixed-ILD
Churg [13]	Not provided	12	12	9	2		13	13	36 (11 months)
Fernandez-Perez [14]	02/2002–07/2006	94	94	30	50		53	53	59 (1 year)
Fumeaux [15]^#	12/1996–03/2001	14	14	11	14	100	100	100
Gaudry [16]	01/2002–04/2009	27	27	22	23	77	85	85	96 (1 year)
Goncalves [17]	01/2004–05/2015	37	37	5	23	62		62	81 (1 month)
Gungor [18]	01/2008–12/2010	120	120	96	72	60		60
Huie [12]	06/2006–04/2009	27	27	13	17		63	63	74 (2 months), 78 (6 months), 85 (1 year)
Martinez [19]^#	12/2007–12/2013	36	36	25	25	55	69	69
Molina- Molina [20]	01/1986–06/2002	20	20	14	20	95	100	100
Olson [21]	01/2005–01/2007	4	4	0	4		100	100
Osman [22]	01/2013–07/2015	91	91	68	9		10	10
Park [23]	1993–04/2006	10	10	0	6		60	60	60 (6 months)
Tachikawa [24]^¶	1/2003–12/2009	62	NI	NI					90 (3 months)
Tomii [25]^¶	10/2001–09/2006	33	NI	NI					46 (2 months)
Vial-Dupuy [26]	7/1993–12/2009	72	72	16	33		46	46
Yokoyama [27]	01/2005–12/2010	38	38	16	21		54	54
Zafrani [28]	01/2002–03/2013	83	83	9	34		41	41	54 (1 years)
Total		780	685	334	353
IPF
Akira [29]^¶	Not provided	17	NI	NI					48 (3 months)
Al-Hameed [30]	09/1988–12/2001	25	25	25	24	84	96	96	100 (1 year)
Ambrosini [31]	05/2001–06/2002	5	5	5	4	80		80	80 (1.5 years)
Blivet [32]	01/1989–06/1998	15	15	15	13	73	86	86
Kim [33]	01/1990–09/2003	11	11	11	7	70	63	63	82 (3 months)
Kondoh [34]	Not provided	3	3	3	0	0	0	0	33 (6 months)
Mollica [35]	01/2000–01/2007	34	34	34	29		85	85	97 (6 months)
Nava [36]	Not provided	7	7	7	6	85		85
Oda [37]	04/2010–03/2013	209	209	209	138		66	66
Papiris [38]	2007–06/2013	17	17	17	11	65		65
Parambil [39]	01/1996–12/2002	7	7	7	6	86	86	86
Rangappa [3]	01/1996–12/2006	24	24	24	22	67	92	92
Saydain [40]	01/1995–07/2000	38	38	38	23	45	61	61
Song [41]	1990–2009	90	90	90	45		50	50
Stern [42]	09/1990–10/1999	23	23	23	22		96	96
Vianello [43]	01/2005–04/2013	18	18	18	10	55		55	86 (3 months), 100 (1 year)
Yokoyama [44]^¶	04/1998–06/2004	11	NI	NI					55 (3 months), 70 (6 months)
Total		554	526	526	360

Data are presented as n, unless otherwise stated. NI: not included in the overall mortality analysis. ^#: patients with radiological diagnosis of usual interstitial pneumonia who were not labelled as IPF in the original study but were considered IPF for our analysis; ^¶: these studies provided information on follow-up mortality only; ⁺: all the patients of 17 studies included in the systematic review; ^§: number of patients included in the ICU and in-hospital mortality analysis, [24, 25, 29, 44] were excluded.