TABLE 1

A few examples of bacterial adhesins in Gram-negative bacteria

ECM components interacting with	NTHi adhesins		M. catarrhalis adhesins		P. aeruginosa adhesins
ECM components interacting with	Name	Characteristics	Name	Characteristics	Name	Characteristics
Collagen	Hap	K_d 20 nM (ELISA), auto-transporter [14]	MID/Hag	Auto-transporter [15]
			UspA2	Trimeric auto-transporter [16, 17]
Fibronectin	Hap	K_d 15 nM (ELISA), auto-transporter [14]	UspA1	Trimeric auto-transporter [16, 18]	OprQ	OprD-family porin [19]
	P4	K_d 10.2 nM (ELISA), lipoprotein [20]	UspA2	Trimeric auto-transporter [16, 18]
Vitronectin	Protein E	K_d 400 nM (surface plasmon resonance), lipoprotein [21, 22]	UspA2	K_d 23 nM (surface plasmon resonance), trimeric auto-transporter [16, 23, 24]	OprD	K_d 3.6 nM (biolayer interferometry), OprD-family porin [25]
	Protein F	K_d 12.8 nM (ELISA), ABC transporter [26]			Lpd	Moonlighting protein [27]
	P4	K_d 16.5 nM (ELISA), lipoprotein [20]
Laminin	Hap	K_d 35 nM (ELISA), auto-transporter [14]	UspA1	Trimeric auto-transporter [16, 28]	Paf	Protein F orthologue [29]
	Protein E	K_d 1.5 μM (surface plasmon resonance), lipoprotein [22, 30]	UspA2	Trimeric auto-transporter [16, 28]
	Protein F	ABC transporter [31]	AfeA	Protein F orthologue [29]
	P4	K_d 9.3 nM (ELISA), lipoprotein [20]

ECM: extracellular matrix; NTHi: nontypeable Haemophilus influenzae; M. catarrhalis: Moraxella catarrhalis; P. aeruginosa: Pseudomonas aeruginosa; Hap: Haemophilus adhesion and penetration protein; K_d : dissociation constant for adhesin–ECM interaction; MID: M. catarrhalis IgD-binding protein; Usp: ubiquitous surface protein; Opr: outer membrane porin; ABC: ATP-binding cassette; Lpd: dihydrolipoamide dehydrogenase.