TABLE 2

Patient clinical characteristics and clinical domains reported in studies

	A	B	C	D	*A versus* B**	*A versus* C**	*B versus* C**	*A versus* D**	*B versus* D**	*C versus* D**
Patients n	144	56	57	98
Age years	63±11	54.6±10.3	64.4±14	67.5±9	0.0001	ns	<0.0001	ns	<0.0001	ns
Female	52.1	71.4	49.1	58.2	0.03	ns	0.01	ns	ns	ns
Gastro-oesophageal reflux	52.8	nr	7	nr		<0.0001
Ever-smoker	54.9	32.1	34	38.8	0.003	0.007	ns	0.01	ns	ns
Systemic corticosteroid use	32.2	81.8	67.9	67.3	<0.0001	<0.0001	ns	<0.0001	ns	ns
BMI kg·m^-2	30±6.6	29.3±5.3	nr	nr	ns
UIP	54.6	8.9	28	0	<0.0001	0.0007	0.009	<0.0001	0.0002	<0.0001
FVC % pred	61.9±18.3	68.4±16	80.2	76.3	ns
D_LCO % pred	45.3±20.6	52.2±15.9	49.3	56.6	ns
FEV₁ L	nr	72.7±16.3	78	nr	ns
TLC L	nr	80.1±13.7	72	nr
Outcome
Death	39.6	0	12.2	27	<0.0001		<0.0001	0.0007	<0.0001	0.03
Lung transplantation	10.3	nr	nr	nr
Domains
C+S	14.6	1.5	11.1	nr	0.01	ns	0.03
C+M	8.3	9	7	nr	ns	ns	ns
S+M	50.7	37.5	52.7	nr	ns	ns	ns
C+S+M	26.4	52	29.2	nr	0.0006	ns	0.01
Treatment	nr	98.2	^#	79.6					0.001
Clinical domain	49.3	62.5	47.3	nr	ns	ns	ns
Mechanic's hands	10.4	28.6	3.5	nr	0.001	ns	0.0003
Distal digital tip ulceration	2.1	0	0	nr	ns	ns	ns
Arthritis or morning stiffness	17.4	16.1	22.8	nr	ns	ns	ns
Palmar telangiectasia	0	5.4	12.2	nr	0.005	<0.0001	ns
Raynaud's phenomenon	27.8	39.3	35	nr	ns	ns	ns
Unexplained digital oedema	3.5	3.6	15.7	nr	ns	0.002	0.02
Gottron's sign	4.9	17.9	5.2	nr	0.003	ns	0.03

Data are presented as mean±sd or %, unless otherwise stated. Bold represents the highest significant value. A: Oldham et al. [18]; B: Chartrand et al. [22]; C: Ahmad et al. [23]; D: Ito et al. [24]; BMI: body mass index; UIP: usual interstitial pneumonia; FVC: forced vital capacity; D_LCO: diffusing capacity of the lung for carbon monoxide; FEV₁: forced expiratory volume in 1 s; TLC: total lung capacity; C: clinical; S: serological; M: morphological; ns: nonsignificant; nr: not reported. ^#: not clearly reported.