Study assessing long-term respiratory outcomes of volume-targeted ventilation versus pressure-controlled mechanical ventilation in preterm infants

Patients nBirthweight; GAAge at time of study#MethodsPrimary outcomeResultsCriticisms
Singh [47]85 (45 VTV + 40 PLV)600–1500 g (mean 1000 g);
24–31 weeks (mean 27 weeks)
2 years (mean 22 months)Randomised within 6 h of MV to receive either PLV or VTV. Parental questionnaire and local paediatricians’ records. Respiratory outcomes: cough and wheeze, inhaled medications and hospital admissions for respiratory illnesses. Neurodevelopmental outcome: cerebral palsy, deafness or blindnessNeurodevelopmental outcome and pulmonary morbidityVTV children, compared to PLV children, required significantly fewer inhaled steroids/bronchodilators. No significant difference in readmission rates, frequency of respiratory illness or neurodevelopmental outcomesNo respiratory functional test. PLV group assessed at a later time (24 months) than the VTV group (18 months). The original study was not powered to look at long-term outcomes

GA: gestational age; VTV: volume-targeted ventilation; PLV: pressure-limited ventilation; MV: mechanical ventilation. #: ages at the study time are given in corrected age.