Acute exacerbation in children's interstitial lung disease

DefinitionA significant worsening of the patient's respiratory condition that necessitates a change in regular management
Criteria (2 criteria are needed to diagnose an acute exacerbation)Increase in respiratory rate ≥20% from baseline
Increase in or development of dyspnoea
Newly developing or increased abnormalities on chest imaging
Onset/increase of oxygen demand to attain the individual baseline saturation (at rest and/or during exercise)
Need for an additional level of ventilatory support (in addition to oxygen)
Decrease in spirometry in children able to perform the tests (≥10%) from baseline for vital capacity
Reduced exercise tolerance in children able to perform the tests (includes desaturation)

Information from [18].