Prognosis of acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) with mechanical ventilation: summary of studies published after 2008
| First author [ref.], country (timeframe) | N | Patients | Methods | Hospital survival | Overall survival |
| Yokoyama [44], Japan (1998–2004) | 11 | MV for AE-IPF | NIV (IMV) CPAP 10 cmH2O, PS/PEEP 5/10 cmH2O | 45% (5/11) 3 month | 45% 3 month |
| Mollica [46], Italy (2000–2007) | 34 | MV for ARF in ICU | IMV or NIV V T 7.5 mL·kg−1 or PS/PEEP 18/7 cmH2O | 15% (5/34) | 3% 6 month |
| Güngör [47], Turkey (2000–2007) | 96 | MV for ARF in ICU | IMV or NIV V T 6–8 mL·kg−1, PEEP 5–7 cm H2O | 36% (35/96) | – |
| Fernández-Pérez [45], USA (2002–2006) | 30 | MV for ARF in ICU | IMV V T 7–8 mL·kg−1 | 40% (12/30) | – |
| Gaudry [48], France (2002–2009) | 22 | MV for ARF in ICU | IMV V T 5.9 mL·kg−1, PEEP 7.1 cm H2O | 23% (5/22) ICU discharge | – |
| Vianello [49], Italy (2005–2013) | 18 | MV for ARF in ICU | NIV (IMV) V T 6–8 mL·kg−1, PEEP 6.4 cm H2O | 14% 90 days | – |
| Total | 193 | 33% (63/193) | 13% |
MV: mechanical ventilation; NIV: noninvasive ventilation; IMV: invasive mechanical ventilation; CPAP: continuous positive pressure ventilation; PS: pressure support; PEEP: positive end-expiratory pressure; ARF: acute respiratory failure; ICU: intensive care unit; VT: tidal volume.