Major overlapping miRNAs in systemic sclerosis (SSc) and idiopathic pulmonary fibrosis (IPF)

FibroblastsSerum expressionSkin expressionFibroblastsSerum expressionLung expression
29a-3pMimic induces apoptosis, abrogates collagen expression, increases collagen degradation↑ in RNP+ compared to ACA+
29b-3pMimic abrogates collagen expression
29c-3pMimic abrogates ECM expressionOverexpression abrogates collagen expression
21-5p↑ in RNP+ compared to ACA+Knockdown abrogates collagen expression and EMT↑ in rapid progressive disease - associated with worse FVC
92a-3pOverexpression induces collagen degradation↔ in SSc and in SSc-ILD
26a-5pOverexpression abrogates collagen expression and EMT
let-7d-5pOverexpression reduces EMT↓ in slowly and rapid progressive disease

The table compares the expression levels and the effects of major overlapping miRNAs in SSc skin and fibroblasts with those observed in IPF lung and fibroblasts. Circulating serum levels for SSc and IPF patients are also reported. RNP+: SSc patients with anti-U1 ribonucleoprotein antibodies; ACA+: SSc patients with anticentromere antibodies; ECM: extracellular matrix; EMT: epithelial–mesenchymal transition; FVC: forced vital capacity; SSc-ILD: systemic sclerosis-associated interstitial lung disease. ↑: high levels; ↓: low levels; ↔: controversial results.