Overview of putative functions of the most relevant microRNAs (miRNAs) overlapping in systemic sclerosis and idiopathic pulmonary fibrosis

Putative functions
miR-29a-3pCollagen gene expression – apoptosis
miR-29b-3pCollagen gene expression
miR-29c-3pECM-related genes expression
miR-21-5pEMT – collagen expression – SMAD7
miR-92a-3pMMP-1 expression
miR-26a-5pEMT – collagen expression

The table shows candidate functions for each major overlapping miRNA in systemic sclerosis and idiopathic pulmonary fibrosis, and provides an overview of the specific functions in fibrogenesis regulated by a specific miRNA. ECM: extracellular matrix; SMAD7: small mother against decapentaplegic protein 7; MMP-1: matrix metalloproteinase 1; EMT: epithelial–mesenchymal transition.