TABLE 1

Overview of putative functions of the most relevant microRNAs (miRNAs) overlapping in systemic sclerosis and idiopathic pulmonary fibrosis

	Putative functions
miR-29a-3p	Collagen gene expression – apoptosis
miR-29b-3p	Collagen gene expression
miR-29c-3p	ECM-related genes expression
miR-21-5p	EMT – collagen expression – SMAD7
miR-92a-3p	MMP-1 expression
miR-26a-5p	EMT – collagen expression
let-7d-5p	EMT

The table shows candidate functions for each major overlapping miRNA in systemic sclerosis and idiopathic pulmonary fibrosis, and provides an overview of the specific functions in fibrogenesis regulated by a specific miRNA. ECM: extracellular matrix; SMAD7: small mother against decapentaplegic protein 7; MMP-1: matrix metalloproteinase 1; EMT: epithelial–mesenchymal transition.