Factors associated with increased risk of mortality in idiopathic pulmonary fibrosis

At baselineLevel of dyspnoea
DLCO <40% predicted
Desaturation <88% during 6MWT
Peak VO2 <8.3 mL·kg−1·min−1 on CPET
Extent of honeycombing on HRCT
Pulmonary hypertension
Longitudinal factorsIncrease in level of dyspnoea
FVC <10% of absolute value
DLCO <15% of absolute value
Worsening of fibrosis on HRCT
  • Information from [9, 12]. DLCO: diffusion capacity of the lung for carbon monoxide; 6MWT: 6-min walk test; VO2: oxygen uptake; CPET: cardiopulmonary exercise test; HRCT: high-resolution computed tomography; FVC: forced vital capacity.