Pathological findings in pulmonary oxygen toxicity and their changes in lung function parameters

Pathological changesIncrease in parameterDecrease in parameter
Interstitial oedemaVC, DLCO, CL,st
Alveolar oedemaVC, DLCO, CL,st
Pulmonary capillary fibrin thrombinVC, DLCO, FeNO
Loss of alveolar type 1 cellVC, DLCO, CL,st
Neutrophilic infiltrationFeNOFeNO
Capillary endothelial lesionsVC, DLCO, CL,st
Interstitial distentionDLCO
Increase alveolar type 2 cellsCL,stDLCO
Infiltration inflammatory cellsFeNO
  • VC: vital capacity; DLCO: diffusing capacity of the lung for carbon monoxide; CL,st: static lung compliance; FeNO: exhaled nitric oxide fraction. Data from [58].